CNOT7 and TOB2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		CNOT7	TOB2
Description		CCR4-NOT transcription complex subunit 7	transducer of ERBB2, 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Cytoplasmic Ribonucleoprotein Granule	Nucleus Cytoplasm Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Transcription Corepressor Activity Protein Binding Nuclear Vitamin D Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Translation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Female Gamete Generation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of DNA-templated Transcription
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278) Vitiligo ( 22561518)
Interacting Genes		29 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI OBI1 PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101	7 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 PABPC1 RPS6KA1 TMEM132D
Entrez ID		29883	10766
HPRD ID		05370	09583
Ensembl ID		ENSG00000198791	ENSG00000183864
Uniprot IDs		Q96IQ6 Q9UIV1	Q14106
PDB IDs		2D5R 4GMJ 7AX1 7VOI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteolysis Histone Kinase Activity Proteasome-activating Activity Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Phorbol 13-acetate 12-myristate Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm CCR4-NOT Complex	Regulation Of Translation Positive Regulation Of MRNA Catabolic Process CCR4-NOT Complex CCR4-NOT Core Complex Poly(A)-specific Ribonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulatory NcRNA-mediated Gene Silencing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication MiRNA-mediated Gene Silencing By MRNA Destabilization Exonuclease Activity Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Cytoplasmic Ribonucleoprotein Granule MRNA Destabilization P-body RNA Destabilization MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Viral Life Cycle Nuclease Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Catabolic Process Nucleic Acid Binding Post-transcriptional Gene Silencing Regulation Of Viral Process MRNA Metabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Protein Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation MRF Binding MCRD-mediated MRNA Stability Complex Ribosomal Protein S6 Kinase Activity Hepatocyte Proliferation PiRNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization
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