IL37 and CASP1

Number of citations of the paper that reports this interaction (PubMedID 12096920)
0

Data Source:
BioGRID (enzymatic study)

		IL37	CASP1
Description		interleukin 37	caspase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding Identical Protein Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Interleukin-37 signaling Interleukin-18 signaling	NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs			Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)	Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		8 interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63	46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14
Entrez ID		27178	834
HPRD ID		05695	00977
Ensembl ID		ENSG00000125571	ENSG00000137752
Uniprot IDs		Q9NZH6	A8K249 A8K257 P29466
PDB IDs		5HN1 6NCU	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA
Enriched GO Terms of Interacting Partners?		Interleukin-18-mediated Signaling Pathway Interleukin-18 Binding Immune System Process NLRP1 Inflammasome Complex Immune Response Response To External Biotic Stimulus Canonical Inflammasome Complex CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Stress Protein Autoprocessing Response To Other Organism Defense Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Pyroptotic Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Microtubule Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Signaling Cellular Response To Oxygen-containing Compound Cysteine-type Endopeptidase Activity Non-canonical Inflammasome Complex Negative Regulation Of Lung Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Regulation Of Interleukin-1 Beta Production Positive Regulation Of Transforming Growth Factor Beta3 Production Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Localization To Extracellular Region Positive Regulation Of Cytokine Production AIM2 Inflammasome Complex Regulation Of Interleukin-1 Production IPAF Inflammasome Complex	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction
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