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IL37 and IL18BP
Number of citations of the paper that reports this interaction (PubMedID
12381835
)
27
Data Source:
HPRD
(in vitro)
IL37
IL18BP
Description
interleukin 37
interleukin 18 binding protein
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Region
Extracellular Space
Extracellular Exosome
Molecular Function
Cytokine Activity
Interleukin-1 Receptor Binding
Protein Binding
Identical Protein Binding
Interleukin-18 Binding
Receptor Antagonist Activity
Biological Process
Inflammatory Response
Immune Response
Cytokine-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Regulation Of Inflammatory Response
Cellular Response To Lipopolysaccharide
Response To Lipopolysaccharide
T-helper 1 Type Immune Response
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Pathways
Interleukin-37 signaling
Interleukin-18 signaling
Interleukin-37 signaling
Interleukin-18 signaling
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
33547301
)
Dysmenorrheic pain severity (
29855537
)
Menstruation quality of life impact (dysmenorrhea) (
29855537
)
Pain medicine use during menstruation (
29855537
)
Pulmonary function (
23932459
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Interacting Genes
8 interacting genes:
CASP1
CASP4
IL18BP
IL18R1
PRKAB2
SMAD3
TRIM55
TRIM63
2 interacting genes:
IL18
IL37
Entrez ID
27178
10068
HPRD ID
05695
04984
Ensembl ID
ENSG00000125571
ENSG00000137496
Uniprot IDs
Q9NZH6
G3V1C5
O95998
PDB IDs
5HN1
6NCU
7AL7
Enriched GO Terms of Interacting Partners
?
Interleukin-18-mediated Signaling Pathway
Interleukin-18 Binding
Immune System Process
NLRP1 Inflammasome Complex
Immune Response
Response To External Biotic Stimulus
Canonical Inflammasome Complex
CARD Domain Binding
Pyroptotic Cell Death
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Response To Stress
Protein Autoprocessing
Response To Other Organism
Defense Response
Negative Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Muscle Hypertrophy
Pyroptotic Inflammatory Response
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Signal Transduction
Positive Regulation Of Cytokine-mediated Signaling Pathway
Microtubule
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Response To Cytokine Stimulus
Positive Regulation Of Signaling
Cellular Response To Oxygen-containing Compound
Cysteine-type Endopeptidase Activity
Non-canonical Inflammasome Complex
Negative Regulation Of Lung Blood Pressure
Regulation Of Cardiac Muscle Hypertrophy
Nuclear Mineralocorticoid Receptor Binding
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Cytokine-mediated Signaling Pathway
Regulation Of Inflammatory Response
AIM2 Inflammasome Complex Assembly
Protease Inhibitor Complex
Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Transforming Growth Factor Beta3 Production
Interleukin-18 Receptor Complex
Interleukin-18 Receptor Activity
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Localization To Extracellular Region
Positive Regulation Of Cytokine Production
AIM2 Inflammasome Complex
Regulation Of Interleukin-1 Production
IPAF Inflammasome Complex
Cytokine Activity
Cellular Response To Molecule Of Bacterial Origin
Interleukin-18 Receptor Binding
Cellular Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Response To Lipopolysaccharide
Cytokine-mediated Signaling Pathway
Inflammatory Response
Positive Regulation Of NK T Cell Proliferation
Positive Regulation Of T-helper 2 Cell Differentiation
Regulation Of Inflammatory Response
Sleep
Positive Regulation Of T-helper 1 Cell Cytokine Production
Cellular Response To Lipid
Positive Regulation Of Natural Killer Cell Proliferation
T-helper 1 Type Immune Response
Type 2 Immune Response
Positive Regulation Of NK T Cell Activation
Interleukin-1 Receptor Binding
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-13 Production
Regulation Of Natural Killer Cell Proliferation
Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Regulation Of Cytokine Production
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Neuroinflammatory Response
Regulation Of Defense Response
Positive Regulation Of Type 2 Immune Response
Response To Lipid
Positive Regulation Of Tissue Remodeling
Positive Regulation Of T-helper 1 Type Immune Response
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Natural Killer Cell Activation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Interleukin-17 Production
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of T-helper Cell Differentiation
Neutrophil Activation
Positive Regulation Of T Cell Cytokine Production
Regulation Of Type 2 Immune Response
Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Regulation Of Activated T Cell Proliferation
Acylglycerol Homeostasis
Immune Response
Regulation Of Natural Killer Cell Activation
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