IL37 and IL18BP

Number of citations of the paper that reports this interaction (PMID 12381835)
30

Data Source:
HPRD (in vitro)

		IL37	IL18BP
Gene Name		interleukin 37	interleukin 18 binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding	Interleukin-18 Binding Receptor Antagonist Activity
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway	Response To Lipopolysaccharide T-helper 1 Type Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Extracellular Negative Regulation Of Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CASP1 CASP4 IL18BP IL18R1 SMAD3	2 interactors: IL18 IL37
Entrez ID		27178	10068
HPRD ID		05695	04984
Ensembl ID		ENSG00000125571	ENSG00000137496
Uniprot IDs		Q9NZH6	G3V1C5 O95998
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production T-helper 1 Type Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Production Immune Response Execution Phase Of Apoptosis Regulation Of Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Transcription Factor Import Into Nucleus Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Transport Zymogen Activation Cellular Response To Organic Substance Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transforming Growth Factor Beta3 Production Interleukin-18-mediated Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Other Organism Positive Regulation Of Transport Positive Regulation Of Endopeptidase Activity Response To Biotic Stimulus Immune System Process Regulation Of Protein Localization Positive Regulation Of Peptidase Activity Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Evasion Or Tolerance Of Host Defenses By Virus Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Apoptotic Process Regulation Of Protein Localization To Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Localization Regulation Of Nucleocytoplasmic Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly	Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of NK T Cell Proliferation Inflammatory Response Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Interleukin-2 Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Positive Regulation Of Alpha-beta T Cell Proliferation Sleep Interferon-gamma Production Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Cytokine Biosynthetic Process Positive Regulation Of Natural Killer Cell Activation T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Cytokine Metabolic Process Immune Response Regulation Of Activated T Cell Proliferation Defense Response Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Interferon-gamma Production Natural Killer Cell Activation Regulation Of Tissue Remodeling Cellular Response To Organic Substance Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Immune System Process Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Organic Substance Cytokine Production
Tagcloud ?			12r 13r 17r a2m ablim actg2 canx fluorochromes fyb gatm hsp75 immunogenesis irf2 lcp1 lsp maoa peci pleurisy ppid scya14 tcralpha tcrbeta tcrdelta tcrgamma tgfb3 thbd trap1 ttid tubercle
Tagcloud (Difference) ?			12r 13r 17r a2m ablim actg2 canx fluorochromes fyb gatm hsp75 immunogenesis irf2 lcp1 lsp maoa peci pleurisy ppid scya14 tcralpha tcrbeta tcrdelta tcrgamma tgfb3 thbd trap1 ttid tubercle
Tagcloud (Intersection) ?