BTG3 and SYNE1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		BTG3	SYNE1
Description		BTG anti-proliferation factor 3	spectrin repeat containing nuclear envelope protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane
	Molecular Function	Protein Binding	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle	Nucleus Organization Golgi Organization Spermatogenesis Cell Differentiation Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane
Pathways			Meiotic synapsis
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy
GWAS		Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)	Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715 21738484 21926972 34002096 28072414 28115744 31043756) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 30194396 31249589 31649266)
Interacting Genes		76 interacting genes: ADNP2 AFF4 AGAP2 AHCYL1 AIP ATXN1 BANP CACNA1A CCDC13 CCT7 CLTC CLU CNOT7 CNOT8 CNTN4 COPS5 CREBZF CRYL1 DCLK2 DDX18 DIS3L DMAP1 DNAJC14 DNAJC7 DYNC1H1 EIF3C EIF3F EPRS1 GLUL HECTD2 HECTD4 HIVEP2 HSP90AA1 HSP90AB1 KCNQ2 KDM3A KIF3A MAPK8IP3 MORF4L1 MRPL38 MTM1 MYCBP2 NISCH NRBP1 OGT OSBPL8 OTOF PAK1 PAX6 PLA2G3 PLEKHB1 PPP2R5E PPP3CA PRKAR1A QARS1 RANBP9 RBL2 RNF10 RSPH1 SEC23IP SETDB1 SMG5 SPARCL1 SRPK2 SYNE1 TAF1 TAF6 TRIM32 TSC2 TSPAN7 USP8 WAPL WDFY3 XPC ZNF532 ZNF592	28 interacting genes: ACTC1 APC BDKRB2 BTG3 CAPN1 CDC42 CDC5L CEP63 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EMD ITSN1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 PCNT SH3BP5 TNIK TP53RK USP21 USP7 XIAP
Entrez ID		10950	23345
HPRD ID		10415	09762
Ensembl ID		ENSG00000154640	ENSG00000131018
Uniprot IDs		Q14201 Q6IAU3	A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91
PDB IDs			4DXR 6R15 6XF2
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Establishment Of Localization In Cell Regulation Of Macromolecule Biosynthetic Process Eukaryotic Translation Initiation Factor 3 Complex Organelle Organization Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process RNA Binding Cytoskeleton Organization Chaperone-mediated Protein Complex Assembly Protein Localization To Organelle Translation Initiation Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Unfolded Protein Binding Regulation Of Gene Expression Translation Intracellular Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Intracellular Protein Localization Disordered Domain Specific Binding Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Telomerase Holoenzyme Complex Assembly Negative Regulation Of Catabolic Process CCR4-NOT Core Complex Chromatin Organization 3'-5'-RNA Exonuclease Activity Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding ATP-dependent Protein Folding Chaperone	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Postsynapse Organization Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cytoskeleton Organization Regulation Of Synapse Organization Microtubule Organizing Center Molecular Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Radial Glia-guided Pyramidal Neuron Migration Antigen Processing And Presentation Centrosome Regulation Of T Cell Mediated Immunity Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell Cycle Natural Killer Cell Mediated Immunity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leading Edge Membrane Positive Regulation Of Lymphocyte Mediated Immunity Glutamatergic Synapse Regulation Of Dendritic Spine Development Positive Regulation Of Adaptive Immune Response Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cytoskeleton Neuron Projection Morphogenesis Cytosol Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Leukocyte Mediated Cytotoxicity Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Regulation Of Protein Localization
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