SDCBP2 and NOP56

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDCBP2	NOP56
Description		syndecan binding protein 2	NOP56 ribonucleoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Nuclear Speck Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	RNA Binding Protein Binding SnoRNA Binding Cadherin Binding Histone Methyltransferase Binding
	Biological Process	Nervous System Development Cell Population Proliferation Intracellular Signal Transduction Intracellular Transport	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways			Association of TriC/CCT with target proteins during biosynthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483)
Interacting Genes		66 interacting genes: ADAP1 AKAP17A AP1M1 ARF4 BEND7 C1orf35 CHCHD1 CRCT1 CRY2 CT45A1 CT45A10 CT45A3 CT45A5 CTH DMC1 DPPA2 EIF1AD FAM133A FAM13C FAM9B FBXO28 GABRA3 HSBP1 LGALS14 LGALS2 LYAR MED4 NFASC NFU1 NKAPD1 NOP56 NPM2 NRXN1 NUF2 PAFAH1B3 PDCD6IP PHC1 PRM2 PRPF38A PRPF40A PRR13 PTMS RNF111 RNPS1 RPL22 RPL22L1 RPL41 SDCBP SEC23A SREK1IP1 SYT17 TCP11L1 TDO2 THAP6 TIFA TM4SF1 TNNT1 TNP1 TRAF1 VAX1 VPS25 YTHDC1 ZCCHC10 ZCCHC17 ZNF581 ZRSR2	9 interacting genes: BMPR2 CSNK2A1 DYNC1LI1 FILNC1 KLF6 PTEN SDCBP2 TCOF1 UBE2I
Entrez ID		27111	10528
HPRD ID		18032	10119
Ensembl ID		ENSG00000125775	ENSG00000101361
Uniprot IDs		Q9H190	O00567
PDB IDs			7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Protein Binding	PML Body Regulation Of Smooth Muscle Cell Proliferation Osteoblast Differentiation Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication Regulation Of Osteoblast Differentiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axonogenesis Regulation Of Intracellular Signal Transduction Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Positive Regulation Of Signaling Regulation Of Epithelial Cell Migration System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Regulation Of Chromosome Segregation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Regulation Of Cell Cycle Phase Transition Intracellular Transport Regulation Of Chromosome Separation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Nucleolar Large RRNA Transcription By RNA Polymerase I RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Early Endosome To Recycling Endosome Transport Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance
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