NOP56 and DYNC1LI1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		NOP56	DYNC1LI1
Description		NOP56 ribonucleoprotein	dynein cytoplasmic 1 light intermediate chain 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Dynein Complex Endocytic Vesicle Membrane Secretory Granule Membrane Recycling Endosome Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding Cadherin Binding Histone Methyltransferase Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding GDP Binding Protein-macromolecule Adaptor Activity Dynein Heavy Chain Binding Molecular Adaptor Activity
	Biological Process	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Microtubule Cytoskeleton Organization Microtubule-based Movement Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Association of TriC/CCT with target proteins during biosynthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 33339817)
Interacting Genes		9 interacting genes: BMPR2 CSNK2A1 DYNC1LI1 FILNC1 KLF6 PTEN SDCBP2 TCOF1 UBE2I	11 interacting genes: BRCA2 CEBPA IKBKG NOP56 NUP85 OGT PGAM2 RAB4A REL RUFY1 SLC25A21-AS1
Entrez ID		10528	51143
HPRD ID		10119	10917
Ensembl ID		ENSG00000101361	ENSG00000144635
Uniprot IDs		O00567	B3KM42 E9PHI6 Q9Y6G9
PDB IDs		7MQ8 7MQ9 7MQA	6B9H 6PSD 6PSE
Enriched GO Terms of Interacting Partners?		PML Body Regulation Of Smooth Muscle Cell Proliferation Osteoblast Differentiation Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication Regulation Of Osteoblast Differentiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axonogenesis Regulation Of Intracellular Signal Transduction Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Positive Regulation Of Signaling Regulation Of Epithelial Cell Migration System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Regulation Of Chromosome Segregation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Regulation Of Cell Cycle Phase Transition Intracellular Transport Regulation Of Chromosome Separation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Nucleolar Large RRNA Transcription By RNA Polymerase I RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Early Endosome To Recycling Endosome Transport Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance
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