NOP56 and KLF6

Number of citations of the paper that reports this interaction (PubMedID 17636026)
56

Data Source:
BioGRID (pull down)

		NOP56	KLF6
Description		NOP56 ribonucleoprotein	KLF transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding Cadherin Binding Histone Methyltransferase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Association of TriC/CCT with target proteins during biosynthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Asthma (bronchodilator response) ( 23508266) Coronary artery calcification ( 23870195) Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Height ( 33713608) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Plasma anti-thyroglobulin levels ( 29678681) Red blood cell count ( 32888494)
Interacting Genes		9 interacting genes: BMPR2 CSNK2A1 DYNC1LI1 FILNC1 KLF6 PTEN SDCBP2 TCOF1 UBE2I	16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53
Entrez ID		10528	1316
HPRD ID		10119	03632
Ensembl ID		ENSG00000101361	ENSG00000067082
Uniprot IDs		O00567	D3GC14 Q99612
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		PML Body Regulation Of Smooth Muscle Cell Proliferation Osteoblast Differentiation Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication Regulation Of Osteoblast Differentiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axonogenesis Regulation Of Intracellular Signal Transduction Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Positive Regulation Of Signaling Regulation Of Epithelial Cell Migration System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Regulation Of Chromosome Segregation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Regulation Of Cell Cycle Phase Transition Intracellular Transport Regulation Of Chromosome Separation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Nucleolar Large RRNA Transcription By RNA Polymerase I RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Early Endosome To Recycling Endosome Transport Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance	Pre-snoRNP Complex Histone Deacetylase Binding Nucleoplasm DNA Binding Box C/D Methylation Guide SnoRNP Complex RNA Metabolic Process Transcription Corepressor Binding Chromatin Remodeling Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Small-subunit Processome TFIID-class Transcription Factor Complex Binding Ribosomal Small Subunit Biogenesis DNA-templated Transcription Transcription Repressor Complex Box C/D SnoRNP Assembly P53 Binding Promoter-specific Chromatin Binding Regulation Of MiRNA Transcription Nucleus Chromatin Organization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II ATPase Binding RRNA Metabolic Process C2H2 Zinc Finger Domain Binding Cellular Response To Oxygen-containing Compound Low-density Lipoprotein Particle Nucleobase-containing Compound Biosynthetic Process Transcription Cis-regulatory Region Binding Histone Methyltransferase Binding Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleolus Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Negative Regulation Of Transcription By RNA Polymerase II SnoRNA Binding Nucleic Acid Metabolic Process High-density Lipoprotein Particle RRNA Transcription Regulation Of RNA Metabolic Process Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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