NOP56 and TCOF1

Number of citations of the paper that reports this interaction (PubMedID 34079125)
0

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		NOP56	TCOF1
Description		NOP56 ribonucleoprotein	treacle ribosome biogenesis factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding Cadherin Binding Histone Methyltransferase Binding	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		Association of TriC/CCT with target proteins during biosynthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Treacher Collins syndrome
GWAS			Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		9 interacting genes: BMPR2 CSNK2A1 DYNC1LI1 FILNC1 KLF6 PTEN SDCBP2 TCOF1 UBE2I	11 interacting genes: CRK CSNK2A1 CSNK2A2 NOP56 PCNA PKNOX1 SPOP SRPK2 TM9SF1 UBC UBTF
Entrez ID		10528	6949
HPRD ID		10119	06026
Ensembl ID		ENSG00000101361	ENSG00000070814
Uniprot IDs		O00567	B4DRA2 E7ETY2 Q13428
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		PML Body Regulation Of Smooth Muscle Cell Proliferation Osteoblast Differentiation Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Cell Communication Regulation Of Osteoblast Differentiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axonogenesis Regulation Of Intracellular Signal Transduction Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Positive Regulation Of Signaling Regulation Of Epithelial Cell Migration System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Regulation Of Chromosome Segregation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Regulation Of Cell Cycle Phase Transition Intracellular Transport Regulation Of Chromosome Separation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Nucleolar Large RRNA Transcription By RNA Polymerase I RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Early Endosome To Recycling Endosome Transport Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance	Protein Kinase CK2 Complex Nucleic Acid Metabolic Process PcG Protein Complex Liver Regeneration Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Helper T Cell Diapedesis Cerebral Cortex Development Protein Phosphorylated Amino Acid Binding Ubiquitin Protein Ligase Binding Receptor Tyrosine Kinase Binding Scaffold Protein Binding Response To Cholecystokinin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Proteasomal Protein Catabolic Process RNA Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Chromosome Separation Animal Organ Regeneration PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Cerebellar Neuron Development Response To Hydrogen Peroxide Protein Serine/threonine Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Liver Development Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Nuclear Speck Organization Regulation Of Glucose Mediated Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Chromosome Segregation Positive Regulation Of Aggrephagy Regeneration Chromatin Binding RNA Polymerase I General Transcription Initiation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity
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