PTPN13 and RAPGEF6

Number of citations of the paper that reports this interaction (PMID 12095257)
18

Data Source:
HPRD (in vitro, two hybrid)

		PTPN13	RAPGEF6
Gene Name		protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	Rap guanine nucleotide exchange factor (GEF) 6
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Vesicular Exosome	Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding GTP-dependent Protein Binding Phosphatidic Acid Binding
	Biological Process	Protein Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation	Ras Protein Signal Transduction Microvillus Assembly Positive Regulation Of Rap GTPase Activity Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: APC ARHGAP29 BRD7 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR NFKBIA NGFR NGFRAP1 PDLIM4 PKN2 PLEKHA1 PRKACA RAPGEF6 TRIP6 YWHAZ	7 interactors: ABCA1 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		5783	51735
HPRD ID		02602	11483
Ensembl ID		ENSG00000163629	ENSG00000158987
Uniprot IDs		Q12923	B2RTU6 Q8TEU7
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ	2D93 3LNY
Enriched GO Terms of Interacting Partners?		Signal Transduction Signaling Cell Communication Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Proliferation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Necroptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Cell Adhesion T Cell Differentiation In Thymus Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Death Cell-cell Junction Organization Motor Neuron Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of Myeloid Leukocyte Differentiation Necroptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Rap Protein Signal Transduction Regulation Of Neuron Differentiation Regulation Of Signal Transduction Establishment Of Protein Localization Regulation Of Cell Differentiation Regulation Of Neurogenesis Ras Protein Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Protein Localization Regulation Of Neuron Projection Development Regulation Of Dendrite Morphogenesis Regulation Of Cell Projection Organization Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Protein Transport Regulation Of Dendrite Development Regulation Of Phosphorus Metabolic Process Generation Of Neurons Small GTPase Mediated Signal Transduction Signal Transduction Neurogenesis Positive Regulation Of Transport Signaling Intracellular Signal Transduction Cellular Response To Organic Substance Interleukin-1 Beta Secretion Cell Communication Regulation Of Cellular Component Organization Membrane Organization Apolipoprotein A-I-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Interleukin-1 Secretion Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Transport Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Nervous System Development Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization System Development Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Regulation Of Protein Phosphorylation
Tagcloud ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Difference) ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Intersection) ?