PTPN13 and ARHGAP29

Number of citations of the paper that reports this interaction (PMID 9305890)
19

Data Source:
HPRD (in vitro)

		PTPN13	ARHGAP29
Gene Name		protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	Rho GTPase activating protein 29
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Rho GTPase Activator Activity PDZ Domain Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			D-dimer levels ( 21502573)
Protein-Protein Interactions		21 interactors: APC ARHGAP29 BRD7 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR NFKBIA NGFR NGFRAP1 PDLIM4 PKN2 PLEKHA1 PRKACA RAPGEF6 TRIP6 YWHAZ	7 interactors: AKT1 CDC42 KDM1A MAGEA11 PTPN13 RAP2A RHOD
Entrez ID		5783	9411
HPRD ID		02602	06674
Ensembl ID		ENSG00000163629
Uniprot IDs		Q12923	Q52LW3
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ
Enriched GO Terms of Interacting Partners?		Signal Transduction Signaling Cell Communication Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Proliferation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Necroptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Cell Adhesion T Cell Differentiation In Thymus Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Death Cell-cell Junction Organization Motor Neuron Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of Myeloid Leukocyte Differentiation Necroptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Regulation Of Cellular Component Organization Regulation Of Organelle Organization Cell Projection Assembly Muscle Cell Differentiation Positive Regulation Of Cell Adhesion Cell Projection Organization Blood Coagulation Hemostasis Endomembrane System Organization Actin Filament Bundle Assembly Cellular Protein Localization T Cell Costimulation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Gland Development Muscle Structure Development Adherens Junction Organization Organelle Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Primitive Erythrocyte Differentiation Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Migration Wound Healing Actin Cytoskeleton Organization Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Cell Motility Myeloid Leukocyte Differentiation Actin Filament-based Process Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Hair Follicle Cell Proliferation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Binding Protein Localization Regulation Of Cellular Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Difference) ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Intersection) ?