PTPN13 and ARHGAP29

Number of citations of the paper that reports this interaction (PubMedID 9305890)
0

Data Source:
HPRD (in vitro)

		PTPN13	ARHGAP29
Description		protein tyrosine phosphatase non-receptor type 13	Rho GTPase activating protein 29
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Cell Projection Cell Body Extracellular Exosome	Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Toxic Substance Negative Regulation Of Excitatory Synapse Assembly	Signal Transduction Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Synthesis of PIPs at the plasma membrane Interleukin-37 signaling RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Tinnitus ( 33742053) Word spelling ( 30741946)	Aspartate aminotransferase levels ( 33547301) D-dimer levels ( 21502573) Plateletcrit ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		26 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 DSCAM EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 VANGL2 YWHAZ	7 interacting genes: HRAS KDM1A MAGEA11 PTPN13 RAP2A RHOA TRIM54
Entrez ID		5783	9411
HPRD ID		02602	06674
Ensembl ID		ENSG00000163629	ENSG00000137962
Uniprot IDs		Q12923	A0A2X0U4J5 Q52LW3
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ 7QCX 7QCY 7XTY
Enriched GO Terms of Interacting Partners?		Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Protein Phosphatase Binding Glutamatergic Synapse Neuron Projection Guidance Axon Guidance Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction CD95 Death-inducing Signaling Complex Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cell Junction Assembly Positive Regulation Of Cell Population Proliferation Tube Formation Death-inducing Signaling Complex Cell Junction Organization Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Regulation Of Intracellular Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Population Proliferation Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Cellular Developmental Process Cell-cell Junction Organization Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Beta-catenin Destruction Complex Positive Regulation Of Apoptotic Process Lateral Plasma Membrane Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Rho Protein Signal Transduction Wnt Signalosome Adherens Junction Nervous System Development Lamellipodium	G Protein Activity Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cellular Response To Gamma Radiation Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Synapse Organization GTPase Activity Response To Gamma Radiation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation GTP Binding Regulation Of Intracellular Signal Transduction GDP Binding Cellular Response To Ionizing Radiation Positive Regulation Of Cell Projection Organization Regulation Of Cell Size Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Neuron Projection Development Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Neuron Apoptotic Process Aortic Valve Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Neural Precursor Cell Proliferation Skeletal Muscle Satellite Cell Migration GTPase Complex Negative Regulation Of Excitatory Synapse Assembly Response To Toxic Substance Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Migration Beta Selection Positive Regulation Of Cell Motility Phospholipase C Activator Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Locomotion Response To Ionizing Radiation Regulation Of JNK Cascade Regulation Of Protein Modification Process Bone Trabecula Morphogenesis Protein Demethylase Activity Negative Regulation Of Metabolic Process Apolipoprotein A-I-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Cytoskeleton Organization
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