BSCL2 and CLDN19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BSCL2	CLDN19
Description		BSCL2 lipid droplet biogenesis associated, seipin	claudin 19
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon
	Molecular Function	Protein Binding Phospholipid Binding	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport
Pathways			Tight junction interactions
Drugs
Diseases		Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN) Hereditary spastic paraplegia (SPG)
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		37 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 SPMIP9 STRIT1 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3	63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14
Entrez ID		26580	149461
HPRD ID		05858	10834
Ensembl ID		ENSG00000168000	ENSG00000164007
Uniprot IDs		A0A024R549 J3KQ12 Q96G97	Q8N6F1
PDB IDs		6DS5
Enriched GO Terms of Interacting Partners?			Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane
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