BSCL2 and UPK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BSCL2	UPK2
Description		BSCL2 lipid droplet biogenesis associated, seipin	uroplakin 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation	Epithelial Cell Differentiation
Pathways
Drugs
Diseases		Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN) Hereditary spastic paraplegia (SPG)
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 31959851)
Interacting Genes		37 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 SPMIP9 STRIT1 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3	36 interacting genes: ADGRG3 AMIGO1 ASGR2 ATP6AP2 BSCL2 BTNL9 C3orf52 CD74 CLDN7 CLEC17A CLEC7A CYB5R3 FCGR1A FCGR2A FCGRT FKBP7 FNDC9 GPA33 HPN ITM2C KASH5 KIR2DL3 KIR3DL3 LIME1 PLP1 RNF170 SLC18A1 SLC22A23 SMAGP STOML3 TMEM106C TMPRSS2 TNFSF11 TNFSF14 UPK1A ZNRF4
Entrez ID		26580	7379
HPRD ID		05858	10295
Ensembl ID		ENSG00000168000	ENSG00000110375
Uniprot IDs		A0A024R549 J3KQ12 Q96G97	O00526
PDB IDs		6DS5
Enriched GO Terms of Interacting Partners?			Membrane Plasma Membrane Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Immune System Process IgG Binding Immune Response Regulation Of Immune Response Regulation Of Immune System Process IgG Receptor Activity Regulation Of Non-canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Activity Immunoglobulin Mediated Immune Response Fucose Binding B Cell Mediated Immunity Antibody-dependent Cellular Cytotoxicity Protein Binding Positive Regulation Of Immune System Process Endoplasmic Reticulum Endoplasmic Reticulum Membrane Hypersensitivity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis, Recognition Positive Regulation Of Immune Response Positive Regulation Of Viral Entry Into Host Cell Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Immune Response-activating Signaling Pathway Regulation Of Viral Entry Into Host Cell D-mannose Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Viral Life Cycle Regulation Of Phagocytosis Positive Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Tumor Necrosis Factor Production MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Lymphocyte Mediated Immunity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production High-affinity IgG Receptor Activity IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Tumor Necrosis Factor Receptor Binding Eye Pigmentation Activation Of Immune Response Detection Of Yeast Detection Of Molecule Of Fungal Origin
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