BSCL2 and SMLR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		BSCL2	SMLR1
Description		BSCL2 lipid droplet biogenesis associated, seipin	small leucine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Membrane
	Molecular Function	Protein Binding Phospholipid Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation
Pathways
Drugs
Diseases		Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN) Hereditary spastic paraplegia (SPG)
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hip circumference adjusted for BMI ( 34021172) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		37 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 SPMIP9 STRIT1 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3	1 interacting genes: BSCL2
Entrez ID		26580	100507203
HPRD ID		05858
Ensembl ID		ENSG00000168000	ENSG00000256162
Uniprot IDs		A0A024R549 J3KQ12 Q96G97	H3BR10
PDB IDs		6DS5
Enriched GO Terms of Interacting Partners?			Lipid Droplet Formation Lipid Storage Negative Regulation Of Lipid Catabolic Process Lipid Droplet Organization Regulation Of Lipid Catabolic Process Lipid Droplet Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Fat Cell Differentiation Phospholipid Binding Regulation Of Cold-induced Thermogenesis
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