RGS17 and RBBP8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RGS17	RBBP8
Gene Name		regulator of G-protein signaling 17	retinoblastoma binding protein 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Nucleolus Transcriptional Repressor Complex
	Molecular Function	GTPase Activator Activity	Single-stranded DNA Endodeoxyribonuclease Activity RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Damaged DNA Binding Protein Binding
	Biological Process	Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic Blastocyst Hatching DNA Repair Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing G2 DNA Damage Checkpoint Cell Division Meiotic Cell Cycle
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (z) signalling events	Meiotic recombination
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Height ( 18391951) Intracranial aneurysm ( 20364137) Tuberculosis ( 20694014)
Protein-Protein Interactions		18 interactors: ADRB2 AQP1 DHX37 GNAI1 GNAI3 HOXA1 LCE2A LCE3C LCE4A NUFIP2 OSTM1 OTX1 PTGER3 RABEP1 RBBP8 RPL10A SMCP TBC1D16	34 interactors: ATM BARD1 BRCA1 CLU CTBP1 CTBP2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 LIMS1 LMO1 LMO2 LMO4 MAP2K4 MRE11A PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 WDYHV1
Entrez ID		26575	5932
HPRD ID		06223	04990
Ensembl ID		ENSG00000091844	ENSG00000101773
Uniprot IDs		Q9UGC6	Q99708
PDB IDs		1ZV4	2L4Z
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Keratinization Heat Generation Keratinocyte Differentiation Membrane Fusion Epidermal Cell Differentiation Temperature Homeostasis Bicarbonate Transport Vesicle Organization Skin Development Regulation Of Body Fluid Levels Vesicle Fusion Regulation Of Adenylate Cyclase Activity Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Abducens Nerve Formation Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Optokinetic Behavior Epidermis Development Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Cellular Response To Retinoic Acid Organelle Fusion Facial Nucleus Development Carbon Dioxide Transmembrane Transport Corticotropin Secretion Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Establishment Or Maintenance Of Actin Cytoskeleton Polarity Developmental Process Regulation Of CAMP Biosynthetic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Metanephric Proximal Convoluted Tubule Development Rhombomere 4 Development Nitric Oxide Transport Semicircular Canal Formation Cellular Response To Mercury Ion Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Renal System Process Regulation Of CAMP Metabolic Process Inner Ear Morphogenesis Membrane Organization Rhombomere 3 Development Rhombomere 5 Development Metanephric Proximal Tubule Development Fever Generation Organ Development Anatomical Structure Development	Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process G2 DNA Damage Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Cell Death Cell Cycle Checkpoint Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Phosphorylation Cell Death Negative Regulation Of Gene Expression Death Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Protein Modification Process Telomere Maintenance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Immune System Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?			advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Difference) ?			advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Intersection) ?