MIS18A and BRD8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MIS18A	BRD8
Description		MIS18 kinetochore protein A	bromodomain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol CENP-A Recruiting Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Chromosome Segregation Heterochromatin Formation CENP-A Containing Chromatin Assembly Cell Division Protein Localization To Chromosome, Centromeric Region Pericentric Heterochromatin Organization	Chromatin Organization Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere	HATs acetylate histones
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)
Interacting Genes		30 interacting genes: ABI3 AIMP2 AMOT ATG14 BRD8 C1orf216 CNGA3 DMAP1 FNDC11 GCSH GLYCTK IFT20 MAFIP MBIP MIS18BP1 NDEL1 NTAQ1 NUP58 OIP5 PPP1R13B RTP5 STX11 STX17 TEDC2 THAP1 TSGA10IP TXLNA VMA22 ZNF471 ZNF655	13 interacting genes: AGTR1 EP400 EP400P1 FSD2 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1
Entrez ID		54069	10902
HPRD ID		10749	04166
Ensembl ID		ENSG00000159055	ENSG00000112983
Uniprot IDs		Q9NYP9	B4DEG9 B4DMS9 B4DN43 Q9H0E9
PDB IDs		7SFY 7SFZ 8S30
Enriched GO Terms of Interacting Partners?		Pericentric Heterochromatin Organization CENP-A Recruiting Complex Autophagosome Membrane Docking Swr1 Complex CENP-A Containing Chromatin Assembly Organelle Localization By Membrane Tethering	Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process NuA4 Histone Acetyltransferase Complex DNA Binding Domain Binding Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Receptor Activity Positive Regulation Of Metabolic Process LBD Domain Binding MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Swr1 Complex Regulation Of DNA Repair Positive Regulation Of DNA Recombination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Monocyte Differentiation Nucleosome Regulation Of Cell Cycle RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Regulation Of Lipid Transport Regulation Of DNA Recombination Negative Regulation Of SMAD Protein Signal Transduction Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Double-strand Break Repair Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Chromatin Organization Transcription Coregulator Binding Regulation Of Cholesterol Efflux
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