CHIC2 and LCE5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHIC2	LCE5A
Description		cysteine rich hydrophobic domain 2	late cornified envelope 5A
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process		Epidermis Development Keratinization
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 28739976 30487518) Serum metabolite levels (CMS) ( 31636271) Subcortical volume (MOSTest) ( 32665545)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma and eczema ( 34155719) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Hair morphology ( 19896111) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory skin disease ( 25574825)
Interacting Genes		68 interacting genes: ADAMTSL4 AGXT AXIN2 C1QTNF2 CARD10 CATSPER1 CBY2 CDR2 CEP44 CYSRT1 DNAL4 FBLN1 GMCL1 HOXA1 ITSN2 KANK2 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LCN2 LZTS2 MDFI MEOX2 MTUS2 MYF5 MYPOP NBPF19 NDUFB7 NOTCH2NLA OTX1 PLEKHF1 PLEKHF2 PLEKHG4 PNMA1 POU4F2 PPARA REL SCNM1 SDCBP TCF4 TOP3B TUBGCP4 U2AF2 ZNF330 ZNF837	88 interacting genes: ADAM12 ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CREB5 CYP21A2 CYSRT1 FBLN1 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-1 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-8 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 NUTF2 PLA2G10 PLAC8 PLSCR2 PLSCR3 PLSCR4 POU4F2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRED2 SPRY1 TGFB1 TRIM42 UBE2I VASN VWC2 VWC2L ZNF655
Entrez ID		26511	254910
HPRD ID		10373	17265
Ensembl ID		ENSG00000109220	ENSG00000186207
Uniprot IDs		Q9UKJ5	Q5TCM9
PDB IDs		8SUV
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Identical Protein Binding Regulation Of Transformation Of Host Cell By Virus Protein Binding	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Phospholipid Scramblase Activity Negative Regulation Of Lens Fiber Cell Differentiation Plasma Membrane Phospholipid Scrambling Cytosol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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