GCDH and ADCY2

Data Source: HiPPIP (Novel)

		GCDH	ADCY2
Name		glutaryl-CoA dehydrogenase	adenylate cyclase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Plasma Membrane Membrane Dendrite Membrane Raft
	Molecular Function	Fatty-acyl-CoA Binding Acyl-CoA Dehydrogenase Activity Glutaryl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Manganese Ion Binding Metal Ion Binding
	Biological Process	L-tryptophan Metabolic Process Acyl-CoA Metabolic Process Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Cellular Response To Forskolin
Pathways		Lysine catabolism	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA	Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	None
GWAS		Clozapine-induced agranulocytosis ( 25187353 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 19862010 27863252 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Serum metabolite levels ( 33031748 )	Anxiety and stress-related disorders ( 31116379 ) Atorvastatin-induced myopathy ( 31220337 ) Bipolar disorder ( 31043756 34002096 24618891 ) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468 ) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468 ) Bipolar I disorder ( 31043756 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Capecitabine sensitivity ( 22864933 ) Coffee consumption ( 31046077 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Food addiction ( 27106561 ) LDL cholesterol levels in HIV infection ( 33109212 ) Mean arterial pressure (alcohol consumption interaction) ( 24376456 ) Oropharynx cancer ( 27749845 ) Pars opercularis volume ( 31530798 ) Plasma factor VII activating protease levels ( 30070759 ) Posterior-cingulate cortex volume ( 31530798 ) Smoking status (heavy vs never) ( 26423011 ) Visceral fat ( 22589738 )
Novel Interactors		3 novel interactors: ADCY2 DNM2 THTPA	8 novel interactors: AHRR CDH18 GCDH ISL1 NUF2 OBP2A RDH12 SLC9A3
Interacting Genes		10 interacting genes: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32	6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2
Entrez ID		2639	108
HPRD ID		01977	00052
Ensembl ID		ENSG00000105607	ENSG00000078295
Uniprot IDs		Q92947	Q08462 Q71UM8
PDB IDs		1SIQ 1SIR 2R0M 2R0N	Not available
GO Terms Enriched among Interactors		Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Amyloid-beta Formation Notch Receptor Processing Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction Growth Cone Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Regulation Of Immune Response Regulation Of Innate Immune Response Magnesium Ion Binding Dendrite Negative Regulation Of Phospholipid Efflux Negative Regulation Of Coagulation Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Calcium Ion Homeostasis Regulation Of Dendritic Spine Development Regulation Of Platelet Activation Negative Regulation Of Hemostasis Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Membrane Fission Aggresome Negative Regulation Of Core Promoter Binding Membrane Protein Proteolysis Thiamine Triphosphate Phosphatase Activity Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Complement Activation, Lectin Pathway Alcohol Metabolic Process Positive Regulation Of Presynaptic Membrane Organization Negative Regulation Of Wound Healing Response To Amyloid-beta Chylomicron Remnant Maintenance Of Location In Cell Regulation Of Blood Coagulation Lipid Transport Involved In Lipid Storage Lipoprotein Particle	G Protein-coupled Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Protein Transport G Protein-coupled Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid CAMP Biosynthetic Process Adenylate Cyclase Activity Response To Alcohol Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Cellular Response To Forskolin Regulation Of Secretion By Cell Response To Forskolin Regulation Of Secretion Cellular Response To Catecholamine Stimulus Phosphorus-oxygen Lyase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G-protein Beta-subunit Binding CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Response To Lipid Heterotrimeric G-protein Complex Regulation Of Biological Quality Nervous System Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Protein Localization System Process Purine-containing Compound Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glutaryl-CoA Dehydrogenase Activity Positive Regulation Of Interleukin-1 Beta Production Nucleoside Phosphate Biosynthetic Process Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Negative Regulation Of Protein Secretion Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Eosinophil Degranulation