GNL3 and ASCC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNL3	ASCC2
Description		G protein nucleolar 3	activating signal cointegrator 1 complex subunit 2
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GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Membrane Nuclear Body Midbody	Nucleus Nucleoplasm Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding GTP Binding MRNA 5'-UTR Binding	Protein Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Stem Cell Division Stem Cell Population Maintenance Positive Regulation Of Telomere Maintenance Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Localization To Chromosome, Telomeric Region	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response Ribosome Disassembly Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Adiponectin levels ( 22479202) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intelligence (MTAG) ( 29326435) Iron status biomarkers (ferritin levels) ( 33536631) Osteoarthritis ( 22763110) Schizophrenia ( 29483656 28991256 25056061 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Spleen volume ( 34128465) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		14 interacting genes: ANXA1 ASCC2 CEP19 DYSF ING4 MDM2 NPM1 OGT PPP2R5A PTEN STAT3 TP53 USP7 WEE2-AS1	41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1
Entrez ID		26354	84164
HPRD ID		06419	16515
Ensembl ID		ENSG00000163938	ENSG00000100325
Uniprot IDs		Q9BVP2	Q9H1I8
PDB IDs		8FKP 8FKR 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2	2DI0 6YXQ
Enriched GO Terms of Interacting Partners?		Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Phase Transition Cellular Response To Actinomycin D Regulation Of Cellular Component Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Organelle Organization Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Regulation Of Protein Stability Response To Actinomycin D Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Protein Localization To Nucleus Cellular Response To UV-C Negative Regulation Of Protein Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Cellular Component Organization Negative Regulation Of MiRNA Processing Negative Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Carbohydrate Catabolic Process Protein-containing Complex P53 Binding Cellular Response To Antibiotic DNA Alkylation Repair Cellular Component Assembly Protein Stabilization Regulation Of Purine Nucleotide Metabolic Process Nucleoplasm Cellular Response To UV Cellular Response To Nutrient Levels Rhythmic Process Response To UV-C Regulation Of MiRNA Processing Regulation Of Cellular Response To Stress Regulation Of Vesicle-mediated Transport Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Regulatory NcRNA Processing Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Autophagy Cellular Response To Light Stimulus Core Promoter Sequence-specific DNA Binding PML Body Regulation Of Cell Communication	Macromolecule Metabolic Process Nucleoplasm
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