GNL3 and PPP2R5A

Number of citations of the paper that reports this interaction (PMID 16097049)
2

Data Source:
HPRD (two hybrid, in vivo)

		GNL3	PPP2R5A
Gene Name		guanine nucleotide binding protein-like 3 (nucleolar)	protein phosphatase 2, regulatory subunit B, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Nucleolus Membrane	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Membrane Z Disc M Band
	Molecular Function	GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding	Protein Binding Protein Phosphatase Type 2A Regulator Activity Kinase Binding
	Biological Process	Metabolic Process Cell Proliferation Regulation Of Cell Proliferation Ribosome Biogenesis	Signal Transduction Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Lipid Kinase Activity
Pathways			Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Adiponectin levels ( 22479202) Bipolar disorder ( 21926972) Bipolar disorder (mood-incongruent) ( 23092984) Osteoarthritis ( 22763110)
Protein-Protein Interactions		5 interactors: ASCC2 MDM2 PPP2R5A STAT3 TP53	18 interactors: APC BCL2 BEST1 CHEK2 CSNK1A1 CTLA4 EIF2AK2 GNL3 JAK2 MAPT NEK1 NOS3 PPP2R1A PTTG1 PYGM SGOL1 SHC1 TP63
Entrez ID		26354	5525
HPRD ID		06419	03384
Ensembl ID		ENSG00000163938	ENSG00000066027
Uniprot IDs		Q9BVP2	Q15172
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV Signal Transduction Involved In Cell Cycle Checkpoint Response To Antibiotic Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Response To Drug Protein Localization To Organelle DNA Damage Response, Signal Transduction By P53 Class Mediator Viral Process Cellular Response To Growth Factor Stimulus Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Response To Growth Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Cellular Response To UV-C Cellular Response To Vitamin B1 Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of Establishment Of Protein Localization Protein Import Into Nucleus Nuclear Import Negative Regulation Of Cellular Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Radiation Negative Regulation Of Catalytic Activity Regulation Of Protein Localization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Protein Import Mitotic Cell Cycle Checkpoint Enzyme Linked Receptor Protein Signaling Pathway Response To Toxic Substance Cellular Response To Nutrient Levels	Mitotic Cell Cycle Process Cell Division Organelle Organization Cellular Response To Stress Mitotic Cell Cycle Regulation Of Protein Metabolic Process Mitotic Nuclear Division Positive Regulation Of Signal Transduction Cell Cycle Process Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus Regulation Of Catalytic Activity Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Apoptotic Process Positive Regulation Of Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Phosphorus Metabolic Process Cell Death Negative Regulation Of Cell Proliferation Death Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Signal Transduction Response To Gamma Radiation Regulation Of Cell Differentiation Cytoskeleton Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Response To Radiation Regulation Of Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Signaling Cell Aging Regulation Of Cell Cycle Phase Transition Regulation Of Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Microtubule Polymerization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity
Tagcloud ?		argues biogenesis card commentary conflicting contradictory dependency explains guanine incurring invertebrate notion nucleolar nucleolus nucleostemin perturbation pointed quintessential reconciled refuted renew ribosomes safeguarding signifies story tantalizing tasking trait unexpected
Tagcloud (Difference) ?		argues biogenesis card commentary conflicting contradictory dependency explains guanine incurring invertebrate notion nucleolar nucleolus nucleostemin perturbation pointed quintessential reconciled refuted renew ribosomes safeguarding signifies story tantalizing tasking trait unexpected
Tagcloud (Intersection) ?