GAPDHS and SH3BP4

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		GAPDHS	SH3BP4
Gene Name		glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	SH3-domain binding protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Sperm Fibrous Sheath Sperm Principal Piece	Nucleus Cytoplasm Coated Pit Clathrin-coated Vesicle Extracellular Vesicular Exosome
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding NADP Binding NAD Binding	GDP-dissociation Inhibitor Activity Protein Binding Ras GTPase Binding Identical Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Sperm Motility Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Oxidation-reduction Process	Endocytosis Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 6-(1,1-Dimethylallyl)-2-(1-Hydroxy-1-Methylethyl)-2,3-Dihydro-7h-Furo[3,2-G]Chromen-7-One N-Naphthalen-1-Ylmethyl-2\'-[3,5-Dimethoxybenzamido]-2\'-Deoxy-Adenosine N-1,2,3,4-Tetrahydronaphth-1-Yl-2\'-[3,5-Dimethoxybenzamido]-2\'-Deoxy-Adenosine
Diseases
GWAS			Dialysis-related mortality ( 21546767) Orofacial clefts ( 22419666)
Protein-Protein Interactions		2 interactors: APP SH3BP4	21 interactors: C2orf73 CCT3 CEP78 CIZ1 DNAJA4 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 TCP1 TTC1 TXNL1 YWHAE YWHAG ZBTB37
Entrez ID		26330	23677
HPRD ID		13566	09285
Ensembl ID		ENSG00000105679	ENSG00000130147
Uniprot IDs		O14556	Q9P0V3
PDB IDs		3H9E 3PFW
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Negative Regulation Of Hydrolase Activity Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Growth Neuron Remodeling Endocytosis Negative Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of TOR Signaling Mating Behavior Negative Regulation Of GTPase Activity Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Autophagy Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway	Protein Folding Toxin Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Heat G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Binding Of Sperm To Zona Pellucida Protein Localization Substantia Nigra Development Response To Temperature Stimulus Sperm-egg Recognition Steroid Hormone Receptor Complex Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Neural Nucleus Development 'de Novo' Posttranslational Protein Folding Positive Regulation Of Mitochondrion Organization 'de Novo' Protein Folding Cell-cell Recognition Cellular Response To Heat Negative Regulation Of Peptidyl-serine Dephosphorylation Cerebellum Structural Organization Regulation Of Heart Rate By Hormone Mitotic Cell Cycle Process Midbrain Development Positive Regulation Of DNA-dependent DNA Replication Initiation Mitotic Cell Cycle Regulation Of Mitochondrion Organization Cell Recognition Single Fertilization Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of DNA-dependent DNA Replication Initiation Cellular Response To Stress Maintenance Of Protein Location In Cell Regulation Of Cell Death
Tagcloud ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced
Tagcloud (Difference) ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced
Tagcloud (Intersection) ?