FBXO4 and CCND1

Number of citations of the paper that reports this interaction (PubMedID 24793136)
58

Data Source:
BioGRID (enzymatic study)

		FBXO4	CCND1
Description		F-box protein 4	cyclin D1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Bicellular Tight Junction Membrane Transcription Repressor Complex Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Proline-rich Region Binding
	Biological Process	Protein Polyubiquitination Telomere Maintenance Cytoplasmic Translational Initiation Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Cellular Homeostasis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Telomere Maintenance Via Telomerase Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Translation Negative Regulation Of Fibroblast Proliferation Cellular Response To Ionizing Radiation Cellular Senescence Membraneless Organelle Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Polyubiquitination Regulation Of DNA Damage Checkpoint	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Liver Development DNA Damage Response Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron Ion Response To X-ray Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Animal Organ Regeneration Mitotic G1 DNA Damage Checkpoint Signaling Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Response To Leptin Fat Cell Differentiation Response To Ethanol Response To Steroid Hormone Cell Division Response To Glucocorticoid Response To Corticosterone Response To Calcium Ion Regulation Of Cell Cycle Mammary Gland Alveolus Development Response To UV-A Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity Regulation of MITF-M-dependent genes involved in cell cycle and proliferation SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs			Acetylsalicylic acid Arsenic trioxide Encorafenib Bryostatin 1
Diseases			Breast cancer Hairy-cell leukemia Oral cancer Multiple myeloma Laryngeal cancer von Hippel-Lindau syndrome Esophageal cancer
GWAS			Adult body size ( 32376654) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Breast cancer ( 20453838 29059683) Breast cancer (early onset) ( 24493630) Breast size ( 22747683 27182965) Cerebral microbleeds ( 32913026) Craniofacial microsomia ( 26853712) Cutaneous malignant melanoma ( 26237428 32341527) Diastolic blood pressure ( 27841878) Height ( 25429064) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Melanoma ( 28212542) Multiple myeloma (IgH translocation) ( 23502783) Nevus count or cutaneous melanoma ( 30429480 32341527) Offspring birth weight ( 31043758) Refractive error ( 32231278) Total body bone mineral density ( 29304378) Type 2 diabetes ( 32499647 30718926 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: CCND1 CDC34 ELF4 HNRNPK SKP1 TERF1 TNNI3K UBE2D2 UBE2D3	82 interacting genes: AKAP8 AMBRA1 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDC14B CDH13 CDK4 CDK6 CDK8 CDKN1A CDKN1B CRYAB CTNNB1 CUL3 DMTF1 DZIP3 EP300 ESR1 FANCC FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 IGFBP3 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PPP3R2 PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SMAD1 SP1 STAT3 TAF1 TBC1D2 TDRD7 THRA THRB TP73 TRMO TSC2 TSTD2 UBTF UHRF2 USP13 XPO1 ZNF510
Entrez ID		26272	595
HPRD ID		09949	01346
Ensembl ID		ENSG00000151876	ENSG00000110092
Uniprot IDs		B3KNA0 D6RAJ6 Q9UKT5	P24385 Q6FI00
PDB IDs		3L2O 3L82 9JKB	2W96 2W99 2W9F 2W9Z 5VZU 6P8E 6P8F 6P8G 6P8H
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleoplasm Nucleus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Post-translational Protein Modification Protein Autoubiquitination Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Macromolecule Catabolic Process Proteasomal Protein Catabolic Process NK T Cell Proliferation F-box Domain Binding Bundle Of His Cell To Purkinje Myocyte Communication Re-entry Into Mitotic Cell Cycle Positive Regulation Of Low-density Lipoprotein Particle Clearance Cul7-RING Ubiquitin Ligase Complex Proteolysis Mitotic Cell Cycle Phase Transition Natural Killer Cell Proliferation Peptidyl-serine Autophosphorylation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Biosynthetic Process Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Protein Catabolic Process Response To Vitamin E Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding	Nucleoplasm Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Population Proliferation Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Hormone DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Cyclin Binding Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of RNA Metabolic Process Cellular Response To Hormone Stimulus G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Transcription Regulator Complex Nucleic Acid Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process
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