FBXO4 and TNNI3K

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBXO4	TNNI3K
Description		F-box protein 4	TNNI3 interacting kinase
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Telomere Maintenance Cytoplasmic Translational Initiation Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Cellular Homeostasis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Telomere Maintenance Via Telomerase Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Translation Negative Regulation Of Fibroblast Proliferation Cellular Response To Ionizing Radiation Cellular Senescence Membraneless Organelle Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Polyubiquitination Regulation Of DNA Damage Checkpoint	Regulation Of Heart Rate Protein Phosphorylation Peptidyl-serine Autophosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 23669352 28892062 26426971 28448500 20935630) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143 33045005) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		9 interacting genes: CCND1 CDC34 ELF4 HNRNPK SKP1 TERF1 TNNI3K UBE2D2 UBE2D3	8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3
Entrez ID		26272	51086
HPRD ID		09949	18208
Ensembl ID		ENSG00000151876	ENSG00000116783
Uniprot IDs		B3KNA0 D6RAJ6 Q9UKT5	Q59H18
PDB IDs		3L2O 3L82 9JKB	4YFF 4YFI 6B5J 7MGJ 7MGK
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleoplasm Nucleus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Post-translational Protein Modification Protein Autoubiquitination Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Macromolecule Catabolic Process Proteasomal Protein Catabolic Process NK T Cell Proliferation F-box Domain Binding Bundle Of His Cell To Purkinje Myocyte Communication Re-entry Into Mitotic Cell Cycle Positive Regulation Of Low-density Lipoprotein Particle Clearance Cul7-RING Ubiquitin Ligase Complex Proteolysis Mitotic Cell Cycle Phase Transition Natural Killer Cell Proliferation Peptidyl-serine Autophosphorylation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Biosynthetic Process Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Protein Catabolic Process Response To Vitamin E Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding	Sarcomere Myosin Binding Cardiac Muscle Contraction Muscle Contraction Mesenchyme Migration Cardiac Muscle Tissue Morphogenesis Muscle System Process Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Cardiac Myofibril Striated Muscle Contraction Actin-myosin Filament Sliding Heart Contraction Heart Process Actin-mediated Cell Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Icosatetraenoic Acid Binding C Zone Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions GAF Domain Binding Filopodium Cell Body Regulation Of Cardiac Muscle Contraction Actin Filament Actin Filament-based Process Tissue Morphogenesis Oleic Acid Binding Regulation Of Striated Muscle Contraction Blood Microparticle Actomyosin Structure Organization Positive Regulation Of Long-chain Fatty Acid Import Into Cell Acetyl-CoA C-myristoyltransferase Activity Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Regulation Of Muscle Filament Sliding Striated Muscle Myosin Thick Filament Cardiac Troponin Complex Troponin C Binding Cytosol Acetyl-CoA C-acyltransferase Activity Troponin T Binding Cytoplasmic Actin-based Contraction Involved In Cell Motility Long-chain Fatty Acid Binding Regulation Of Phosphatidylcholine Biosynthetic Process System Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of Muscle Contraction Lamellipodium Enoyl-CoA Hydratase Activity
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