FBXO4 and ELF4

Number of citations of the paper that reports this interaction (PMID 16581786)
13

Data Source:
HPRD (in vivo)

		FBXO4	ELF4
Gene Name		F-box protein 4	E74-like factor 4 (ets domain transcription factor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm SCF Ubiquitin Ligase Complex	Nucleoplasm PML Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	Protein Polyubiquitination Telomere Maintenance Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination	Natural Killer Cell Proliferation NK T Cell Proliferation Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CCND1 CDC34 ELF4 SKP1 TERF1 UBE2D2	9 interactors: CASP4 FBXO4 FBXO7 NPM1 PML RUNX1 SET SKP2 UBB
Entrez ID		26272	2000
HPRD ID		09949	06499
Ensembl ID		ENSG00000151876	ENSG00000102034
Uniprot IDs		B3KNA0 D6RAJ6 Q9UKT5	Q99607
PDB IDs		3L2O 3L82
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Protein K48-linked Ubiquitination Cell Cycle Process Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Natural Killer Cell Proliferation Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication NK T Cell Proliferation Notch Signaling Pathway Chromatin Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Alpha-beta T Cell Proliferation Telomeric Loop Formation Age-dependent Telomere Shortening Re-entry Into Mitotic Cell Cycle Protein Polyubiquitination Cellular Macromolecule Catabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Response To UV-A Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling DNA Replication Positive Regulation Of Cell Cycle Replicative Cell Aging Positive Regulation Of Cellular Component Biogenesis Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Transferase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Proteolysis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Protein Ubiquitination Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cytoplasmic Transport Regulation Of Apoptotic Process Mitotic Cell Cycle Nucleocytoplasmic Transport Intracellular Transport Nuclear Transport Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Cell Aging Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest
Tagcloud ?		allosteric braf cdk4 collectively contributor cyclin d1 deficiency depends directs disrupts dysregulation e3 i377m inactivated ink4a ligase malignancy melanoma melanomagenesis melanomas neoplastic p16 preserving proteolysis timely transforming trf1 underscoring	6h arabidopsis arrythmo circadian clock compromised cop1 cycles dark darkness diel elf3 elip1 example flowering influenced light lux night periods photomorphogenic plants prr9 pseudo seedlings sensing subjective uv uvr8
Tagcloud (Difference) ?		allosteric braf cdk4 collectively contributor cyclin d1 deficiency depends directs disrupts dysregulation e3 i377m inactivated ink4a ligase malignancy melanoma melanomagenesis melanomas neoplastic p16 preserving proteolysis timely transforming trf1 underscoring	6h arabidopsis arrythmo circadian clock compromised cop1 cycles dark darkness diel elf3 elip1 example flowering influenced light lux night periods photomorphogenic plants prr9 pseudo seedlings sensing subjective uv uvr8
Tagcloud (Intersection) ?