FBXO4

Description		F-box protein 4
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Polyubiquitination Telomere Maintenance Cytoplasmic Translational Initiation Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Cellular Homeostasis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Telomere Maintenance Via Telomerase Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Translation Negative Regulation Of Fibroblast Proliferation Cellular Response To Ionizing Radiation Cellular Senescence Membraneless Organelle Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Polyubiquitination Regulation Of DNA Damage Checkpoint
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: CCND1 CDC34 ELF4 HNRNPK SKP1 TERF1 TNNI3K UBE2D2 UBE2D3
Entrez ID		26272
HPRD ID		09949
Ensembl ID		ENSG00000151876
Uniprot IDs		B3KNA0 D6RAJ6 Q9UKT5
PDB IDs		3L2O 3L82 9JKB
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleoplasm Nucleus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Post-translational Protein Modification Protein Autoubiquitination Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Macromolecule Catabolic Process Proteasomal Protein Catabolic Process NK T Cell Proliferation F-box Domain Binding Bundle Of His Cell To Purkinje Myocyte Communication Re-entry Into Mitotic Cell Cycle Positive Regulation Of Low-density Lipoprotein Particle Clearance Cul7-RING Ubiquitin Ligase Complex Proteolysis Mitotic Cell Cycle Phase Transition Natural Killer Cell Proliferation Peptidyl-serine Autophosphorylation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Biosynthetic Process Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Protein Catabolic Process Response To Vitamin E Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding
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