FBXO4

Gene Name		F-box protein 4
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Polyubiquitination Telomere Maintenance Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination
Pathways		Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: CCND1 CDC34 ELF4 SKP1 TERF1 UBE2D2
Entrez ID		26272
HPRD ID		09949
Ensembl ID		ENSG00000151876
Uniprot IDs		B3KNA0 D6RAJ6 Q9UKT5
PDB IDs		3L2O 3L82
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Protein K48-linked Ubiquitination Cell Cycle Process Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Natural Killer Cell Proliferation Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication NK T Cell Proliferation Notch Signaling Pathway Chromatin Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Alpha-beta T Cell Proliferation Telomeric Loop Formation Age-dependent Telomere Shortening Re-entry Into Mitotic Cell Cycle Protein Polyubiquitination Cellular Macromolecule Catabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Response To UV-A Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling DNA Replication Positive Regulation Of Cell Cycle Replicative Cell Aging Positive Regulation Of Cellular Component Biogenesis Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity
Tagcloud ?		allosteric braf cdk4 collectively contributor cyclin d1 deficiency depends directs disrupts dysregulation e3 i377m inactivated ink4a ligase malignancy melanoma melanomagenesis melanomas neoplastic p16 preserving proteolysis timely transforming trf1 underscoring