GATA6 and KPNA3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GATA6	KPNA3
Gene Name		GATA binding protein 6	karyopherin alpha 3 (importin alpha 4)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Nuclear Pore Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Protein Transporter Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Liver Development Outflow Tract Septum Morphogenesis Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Transcription From RNA Polymerase II Promoter Phospholipid Metabolic Process Endodermal Cell Fate Determination Blood Coagulation Male Gonad Development Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta2 Production Response To Drug Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Formation Smooth Muscle Cell Differentiation Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Lung Saccule Development Clara Cell Differentiation Type II Pneumocyte Differentiation Intestinal Epithelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Response To Growth Factor Positive Regulation Of Cell Cycle Arrest Cellular Response To Gonadotropin Stimulus Cellular Response To Hypoxia Cellular Response To BMP Stimulus	Protein Complex Assembly NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Viral Entry Into Host Cell Viral Penetration Into Host Nucleus
Pathways		Factors involved in megakaryocyte development and platelet production	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Tuberculosis ( 20694014)	Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: CRIP2 EP300 HHEX KLF2 KPNA3 MED1 NKX2-1	28 interactors: APOL6 CDKN1B COIL DDX21 EPHA2 ERCC3 FAM50B FTL GATA6 GTF2H1 HNRNPC KPNB1 MAT2B MTA1 MVP MYOD1 NFE2L2 NFKB1 NUP50 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TSSC4 ZBTB24 ZCCHC10 ZNF131
Entrez ID		2627	3839
HPRD ID		09043	03536
Ensembl ID		ENSG00000141448	ENSG00000102753
Uniprot IDs		Q53EU2 Q92908	O00505 Q8IYQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Lung Development Respiratory Tube Development Tube Development Respiratory System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Epithelial Cell Differentiation Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Hemopoiesis Positive Regulation Of Macromolecule Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Gene Expression Thyroid Gland Development Immune System Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Morphogenesis Of A Branching Epithelium Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Cell Differentiation Tissue Development Chordate Embryonic Development Morphogenesis Of A Branching Structure Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Response To Hormone Epithelial Tube Branching Involved In Lung Morphogenesis Organ Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune System Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Lung Epithelial Cell Differentiation Epithelial Tube Morphogenesis Negative Regulation Of Transcription, DNA-templated Lung Cell Differentiation Transcription, DNA-templated Lung Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Lung Epithelium Development System Development RNA Biosynthetic Process Anatomical Structure Morphogenesis Tube Morphogenesis Embryonic Heart Tube Development Positive Regulation Of Cellular Metabolic Process	Viral Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Response To Organic Substance Nitrogen Compound Metabolic Process Gene Expression Nucleotide-excision Repair, DNA Damage Removal Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Termination Of RNA Polymerase I Transcription Programmed Cell Death Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process Osteoblast Differentiation Transcription Initiation From RNA Polymerase I Promoter Cell Death Death 7-methylguanosine MRNA Capping Response To Abiotic Stimulus Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Metabolic Process Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription Positive Regulation Of Wound Healing Regulation Of Nucleic Acid-templated Transcription Cellular Response To DNA Damage Stimulus Regulation Of RNA Biosynthetic Process Response To Lipid Response To Estrogen Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-12 Biosynthetic Process Nucleotide-excision Repair, DNA Duplex Unwinding Notochord Cell Development Regulation Of Cell Cycle Process Cellular Macromolecule Catabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk	alpha4 ataxias capicua desensitize erk ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar
Tagcloud (Difference) ?		adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk	alpha4 ataxias capicua desensitize erk ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar
Tagcloud (Intersection) ?