GATA6 and KLF2

Number of citations of the paper that reports this interaction (PMID 11375995)
17

Data Source:
BioGRID (two hybrid)

		GATA6	KLF2
Gene Name		GATA binding protein 6	Kruppel-like factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Liver Development Outflow Tract Septum Morphogenesis Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Transcription From RNA Polymerase II Promoter Phospholipid Metabolic Process Endodermal Cell Fate Determination Blood Coagulation Male Gonad Development Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta2 Production Response To Drug Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Formation Smooth Muscle Cell Differentiation Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Lung Saccule Development Clara Cell Differentiation Type II Pneumocyte Differentiation Intestinal Epithelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Response To Growth Factor Positive Regulation Of Cell Cycle Arrest Cellular Response To Gonadotropin Stimulus Cellular Response To Hypoxia Cellular Response To BMP Stimulus	Cell Morphogenesis In Utero Embryonic Development Transcription, DNA-templated Negative Regulation Of Interleukin-6 Production Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression, Epigenetic Erythrocyte Maturation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Cycloheximide Cellular Response To Laminar Fluid Shear Stress Cellular Response To Peptide
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Tuberculosis ( 20694014)
Protein-Protein Interactions		7 interactors: CRIP2 EP300 HHEX KLF2 KPNA3 MED1 NKX2-1	6 interactors: EP300 GATA5 GATA6 GSK3B KAT2B WWP1
Entrez ID		2627	10365
HPRD ID		09043	03602
Ensembl ID		ENSG00000141448	ENSG00000127528
Uniprot IDs		Q53EU2 Q92908	Q8IUN4 Q9Y5W3
PDB IDs
Enriched GO Terms of Interacting Partners?		Lung Development Respiratory Tube Development Tube Development Respiratory System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Epithelial Cell Differentiation Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Hemopoiesis Positive Regulation Of Macromolecule Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Gene Expression Thyroid Gland Development Immune System Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Morphogenesis Of A Branching Epithelium Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Cell Differentiation Tissue Development Chordate Embryonic Development Morphogenesis Of A Branching Structure Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Response To Hormone Epithelial Tube Branching Involved In Lung Morphogenesis Organ Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune System Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Lung Epithelial Cell Differentiation Epithelial Tube Morphogenesis Negative Regulation Of Transcription, DNA-templated Lung Cell Differentiation Transcription, DNA-templated Lung Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Lung Epithelium Development System Development RNA Biosynthetic Process Anatomical Structure Morphogenesis Tube Morphogenesis Embryonic Heart Tube Development Positive Regulation Of Cellular Metabolic Process	N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Intestinal Epithelial Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To BMP Stimulus Cellular Response To Organic Substance N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Regulation Of RNA Metabolic Process Positive Regulation Of Stem Cell Differentiation Response To Organic Substance Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Heat Positive Regulation Of Protein Binding Negative Regulation Of Biosynthetic Process Muscle Structure Development Viral Process Histone H2B Acetylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Growth Factor Stimulus Regulation Of Glucose Metabolic Process ER-nucleus Signaling Pathway Response To Growth Factor Cellular Response To Oxygen Levels Response To Heat Positive Regulation Of Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Tissue Development Positive Regulation Of Binding Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Histone H3-K9 Acetylation Negative Regulation Of Type B Pancreatic Cell Development
Tagcloud ?		adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk	92a ameliorates atherogenesis attenuates bioavailability challenged disrupts dysfunctional ecs enos exacerbates hypercholesterolemic inflammasome infused innate klf4 kruppel lna locked microrna nlrp3 nucleic postulated pyrin sirtuin srebp2 sterol stresses vasodilation
Tagcloud (Difference) ?		adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk	92a ameliorates atherogenesis attenuates bioavailability challenged disrupts dysfunctional ecs enos exacerbates hypercholesterolemic inflammasome infused innate klf4 kruppel lna locked microrna nlrp3 nucleic postulated pyrin sirtuin srebp2 sterol stresses vasodilation
Tagcloud (Intersection) ?