GATA6 and HHEX

Number of citations of the paper that reports this interaction (PMID 15016828)
18

Data Source:
HPRD (two hybrid)

		GATA6	HHEX
Gene Name		GATA binding protein 6	hematopoietically expressed homeobox
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Nucleus Cytoplasm Protein-DNA Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Transcription Factor Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Liver Development Outflow Tract Septum Morphogenesis Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Transcription From RNA Polymerase II Promoter Phospholipid Metabolic Process Endodermal Cell Fate Determination Blood Coagulation Male Gonad Development Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta2 Production Response To Drug Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Formation Smooth Muscle Cell Differentiation Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Lung Saccule Development Clara Cell Differentiation Type II Pneumocyte Differentiation Intestinal Epithelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Response To Growth Factor Positive Regulation Of Cell Cycle Arrest Cellular Response To Gonadotropin Stimulus Cellular Response To Hypoxia Cellular Response To BMP Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis In Utero Embryonic Development Myeloid Leukocyte Differentiation Transcription, DNA-templated MRNA Export From Nucleus Endoderm Development Cell Proliferation Response To Wounding Anterior/posterior Pattern Specification Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Poly(A)+ MRNA Export From Nucleus Interkinetic Nuclear Migration Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Thyroid Gland Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Protein Localization To Nucleus Embryonic Heart Tube Development Multicellular Organism Growth Regulation Of Cell Proliferation Response To Peptide Hormone Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Forebrain Morphogenesis Primary Lung Bud Formation Gall Bladder Development Hepatic Duct Development Hepatoblast Differentiation Hepatocyte Differentiation DNA Conformation Change Primitive Streak Formation
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Tuberculosis ( 20694014)	Dehydroepiandrosterone sulphate levels ( 21533175) Multiple sclerosis ( 21833088) Type 2 diabetes ( 18372903 17293876 22693455 20862305 20581827 19401414 17463246 17463248 17463249)
Protein-Protein Interactions		7 interactors: CRIP2 EP300 HHEX KLF2 KPNA3 MED1 NKX2-1	15 interactors: EFEMP2 GATA2 GATA6 JUN KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP4-12 PML PSMA3 SOX10 SOX8 TLE1 TRMT6
Entrez ID		2627	3087
HPRD ID		09043	06829
Ensembl ID		ENSG00000141448
Uniprot IDs		Q53EU2 Q92908	Q03014
PDB IDs			2E1O
Enriched GO Terms of Interacting Partners?		Lung Development Respiratory Tube Development Tube Development Respiratory System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Epithelial Cell Differentiation Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Hemopoiesis Positive Regulation Of Macromolecule Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Gene Expression Thyroid Gland Development Immune System Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Morphogenesis Of A Branching Epithelium Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Cell Differentiation Tissue Development Chordate Embryonic Development Morphogenesis Of A Branching Structure Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Response To Hormone Epithelial Tube Branching Involved In Lung Morphogenesis Organ Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune System Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Lung Epithelial Cell Differentiation Epithelial Tube Morphogenesis Negative Regulation Of Transcription, DNA-templated Lung Cell Differentiation Transcription, DNA-templated Lung Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Lung Epithelium Development System Development RNA Biosynthetic Process Anatomical Structure Morphogenesis Tube Morphogenesis Embryonic Heart Tube Development Positive Regulation Of Cellular Metabolic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Organ Morphogenesis Positive Regulation Of Cell Cycle Arrest RNA Metabolic Process Cell Fate Commitment SMAD Protein Import Into Nucleus Tube Development Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Cell Cycle Arrest RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Macromolecule Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Maturation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Gland Development In Utero Embryonic Development Epithelium Development Organ Development Epithelial Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Process Regulation Of Gene Expression
Tagcloud ?		adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk	beyond circulation clp definitive deleted dendritic deregulated developmental functioning hematopoiesis hematopoietic hematopoietically homeobox knockout lineages lymphoid nk null overexpressed precursors progenitors progressive regulators rescue spleen stem subsets tolerated transitional
Tagcloud (Difference) ?		adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk	beyond circulation clp definitive deleted dendritic deregulated developmental functioning hematopoiesis hematopoietic hematopoietically homeobox knockout lineages lymphoid nk null overexpressed precursors progenitors progressive regulators rescue spleen stem subsets tolerated transitional
Tagcloud (Intersection) ?