CARM1 and SRCAP

Number of citations of the paper that reports this interaction (PubMedID 14500758)
0

Data Source:
HPRD (two hybrid, in vivo)

		CARM1	SRCAP
Description		coactivator associated arginine methyltransferase 1	Snf2 related CREBBP activator protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Replication Fork	Nucleosome Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus Nuclear Body Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H3R17 Methyltransferase Activity Histone Methyltransferase Activity Histone H3R2 Methyltransferase Activity DNA-binding Transcription Factor Binding	Nucleotide Binding DNA Binding Transcription Coactivator Activity Helicase Activity Histone Acetyltransferase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding Catalytic Activity, Acting On A Protein
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Positive Regulation Of Cell Population Proliferation Methylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase I Response To CAMP Replication Fork Reversal Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Dendrite Development	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624)	Immunoglobulin light chain (AL) amyloidosis ( 28025584) Multiple myeloma ( 33875642) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469)
Interacting Genes		34 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I	6 interacting genes: ATG9A CARM1 CREBBP KAT2B NCOA2 SUMO2
Entrez ID		10498	10847
HPRD ID		09158	18103
Ensembl ID		ENSG00000142453	ENSG00000080603
Uniprot IDs		Q86X55	Q6ZRS2
PDB IDs		2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C 7FAI 7FAJ 7U9I 8G2H 8G2I 8SIG 8SIH	6IGM 8X15 8X19 8X1C
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Transcription Coactivator Activity Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Enzyme Binding Muscle Cell Differentiation Positive Regulation Of Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Regulation Of Cell Development	N-terminal Peptidyl-lysine Acetylation Transcription Coactivator Activity Peptidyl-lysine Acetylation Transcription Coregulator Activity N-terminal Protein Amino Acid Acetylation Acetyltransferase Activity DNA-binding Transcription Factor Binding Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Acetyltransferase Activity Protein Acetylation Rhythmic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Smoothened Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Histone H3K27 Acetyltransferase Activity Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H3R17 Methyltransferase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Histone H3K18 Acetyltransferase Activity Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Peptide Lactyltransferase (CoA-dependent) Activity Diamine N-acetyltransferase Activity Histone Arginine N-methyltransferase Activity Cellular Response To Thyroglobulin Triiodothyronine Acyltransferase Activity Negative Regulation Of Ribosome Biogenesis MRF Binding Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Replication Fork Reversal Response To Thyroglobulin Triiodothyronine
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