CARM1 and DAXX

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		CARM1	DAXX
Description		coactivator associated arginine methyltransferase 1	death domain associated protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Replication Fork	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nuclear Body PML Body
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H3R17 Methyltransferase Activity Histone Methyltransferase Activity Histone H3R2 Methyltransferase Activity DNA-binding Transcription Factor Binding	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Nuclear Androgen Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Molecular Condensate Scaffold Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Positive Regulation Of Cell Population Proliferation Methylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase I Response To CAMP Replication Fork Reversal Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Dendrite Development	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process JNK Cascade Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Cellular Response To Sodium Arsenite
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs
Diseases
GWAS		C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624)	Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		34 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I	114 interacting genes: ACVR2A AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CEP63 CEP70 CFLAR CREBBP CSNK2A1 CSNK2B DAPK3 DKC1 DMAP1 DNMT1 DRC4 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 GOLGA6L9 GRIPAP1 H3-3B H3-5 H3C3 H4C16 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 WEE2-AS1 ZBTB2 ZBTB26
Entrez ID		10498	1616
HPRD ID		09158	04424
Ensembl ID		ENSG00000142453	ENSG00000204209
Uniprot IDs		Q86X55	A0A024RCS3 B4E1C1 Q53F85 Q9UER7
PDB IDs		2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C 7FAI 7FAJ 7U9I 8G2H 8G2I 8SIG 8SIH	2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Transcription Coactivator Activity Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Enzyme Binding Muscle Cell Differentiation Positive Regulation Of Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Regulation Of Cell Development	PML Body Identical Protein Binding Nucleus Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process PML Body Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Nuclear Body Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death
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