GAS1 and BIRC2

Number of citations of the paper that reports this interaction (PMID 11906213)
7

Data Source:
HPRD (in vivo)

		GAS1	BIRC2
Gene Name		growth arrest-specific 1	baculoviral IAP repeat containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane	XY Body Nucleus Cytoplasm Cytosol Spindle Microtubule Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein N-terminus Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Cell Cycle Arrest Axon Guidance Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Programmed Cell Death Cerebellum Morphogenesis Dorsal/ventral Neural Tube Patterning Negative Regulation Of Cell Growth Cellular Response To Vascular Endothelial Growth Factor Stimulus Outer Ear Morphogenesis Middle Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Camera-type Eye Development Cell Fate Commitment Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Developmental Growth Eye Morphogenesis Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Palate Development Regulation Of ER To Golgi Vesicle-mediated Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Polyubiquitination Response To Hypoxia Placenta Development Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Regulation Of Inflammatory Response Protein Heterooligomerization Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Hedgehog 'on' state Signaling by Hedgehog Ligand-receptor interactions	Apoptotic cleavage of cellular proteins IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death Innate Immune System
Drugs
Diseases
GWAS		Insulin resistance/response ( 21901158)	Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: BIRC2 DLK1 SHH	58 interactors: BIRC5 BIRC7 BOLA1 CASP2 CASP3 CASP7 CASP9 CBLC CD40 DIABLO DZIP3 EAF2 EXOSC5 FBXO7 GAS1 GCC1 GFAP GSPT1 HSP90B1 HTRA2 IKBKE IKBKG JUP LTBR MAGEA11 MAP3K2 MAP3K3 NMB OTUB1 PACS2 PCSK9 PPM1K RAC1 RAF1 RHOA RIPK1 RIPK2 RIPK3 RIPK4 RNF181 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2Q2 UBE2S UBE2V1 UBE2W WDYHV1
Entrez ID		2619	329
HPRD ID		00747	03419
Ensembl ID		ENSG00000180447	ENSG00000110330
Uniprot IDs		P54826	Q13490
PDB IDs			1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4LGE 4LGU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Sclerotome Development Multicellular Structure Septum Development Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Embryonic Skeletal System Development Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Right Lung Development Primary Prostatic Bud Elongation Intein-mediated Protein Splicing Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Polarity Specification Of Anterior/posterior Axis Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Left Lung Development Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Monoubiquitination Positive Regulation Of Immature T Cell Proliferation In Thymus Cell Proliferation In Hindbrain Positive Regulation Of Smooth Muscle Cell Differentiation Prostate Epithelial Cord Elongation Specification Of Axis Polarity Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Hh Target Transcription Factor Activity Negative Regulation Of Cholesterol Efflux Negative Regulation Of Proteolysis Positive Regulation Of Immature T Cell Proliferation Regulation Of Protein K63-linked Ubiquitination Bud Outgrowth Involved In Lung Branching Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Negative Regulation Of Protein Processing Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Regulation Of Nodal Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ventral Midline Development Regulation Of Protein Processing Negative Regulation Of Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Lung Development Salivary Gland Cavitation Bergmann Glial Cell Differentiation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Programmed Cell Death Cell Death Death Apoptotic Process Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Protein Ubiquitination Cellular Response To Stress Regulation Of Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein Processing Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Protein Catabolic Process Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Transferase Activity Response To Stress Cellular Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process
Tagcloud ?		acids ankyrin cca1 cca2 cca3 cdna cloning consist copies decrease encoding frame hepatectomy initiation kinetics level mrna nucleotide nucleotides open partial rapid rat reading regenerating repeat sequencing synthesis transient	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Difference) ?		acids ankyrin cca1 cca2 cca3 cdna cloning consist copies decrease encoding frame hepatectomy initiation kinetics level mrna nucleotide nucleotides open partial rapid rat reading regenerating repeat sequencing synthesis transient	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Intersection) ?