GAS1 and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		GAS1	PTPRA
Description		growth arrest specific 1	protein tyrosine phosphatase receptor type A
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GO Annotations	Cellular Component	Plasma Membrane Membrane Side Of Membrane	Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Oxysterol Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of Cell Cycle Regulation Of ER To Golgi Vesicle-mediated Transport	Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Focal Adhesion Assembly
Pathways		Ligand-receptor interactions Activation of SMO	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: BIRC2 DLK1 ERRFI1 PTPRA SHH	20 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GAS1 GRB2 HSPB1 HUNK KCNA2 LCOR LINC00839 MBP PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		2619	5786
HPRD ID		00747	01476
Ensembl ID		ENSG00000180447	ENSG00000132670
Uniprot IDs		P54826	A0A1S5UZ22 B7Z2A4 P18433
PDB IDs		7RHQ	6UZT
Enriched GO Terms of Interacting Partners?		Lung Epithelium Development Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Collagen Type XV Trimer Steroid Metabolic Process Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Skin Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Vasculature Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Protein K48-linked Ubiquitination FBXO Family Protein Binding Nitric-oxide Synthase Complex Cholesterol Metabolic Process Sterol Metabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Intein-mediated Protein Splicing Cholesterol-protein Transferase Activity Prostate Epithelial Cord Elongation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Skeletal Muscle Cell Proliferation Bud Outgrowth Involved In Lung Branching Ventral Midline Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Specification Of Axis Polarity Trachea Morphogenesis Trachea Development Negative Regulation Of Dopaminergic Neuron Differentiation Hindgut Morphogenesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Positive Regulation Of Protein Monoubiquitination Nitrite Reductase (NO-forming) Activity Salivary Gland Cavitation Mesenchymal Cell Proliferation Involved In Lung Development Epithelial-mesenchymal Cell Signaling Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Trunk Neural Crest Cell Migration	Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Synaptic Membrane Adhesion Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Tyrosine Phosphatase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity T Cell Costimulation Cell-cell Adhesion Phosphoprotein Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Response To Growth Factor Fc Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Phospholipase Activator Activity Regulation Of Apoptotic Signaling Pathway Immune Effector Process Regulation Of Immune Response Cell-cell Junction Regulation Of Cell Migration ERBB Signaling Pathway Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Membrane Regulation Of Cell Motility Regulation Of Neuron Projection Development Protein Tyrosine Kinase Activator Activity
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