GAS1

Description		growth arrest specific 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Protein Binding Oxysterol Binding
	Biological Process	Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of Cell Cycle Regulation Of ER To Golgi Vesicle-mediated Transport
Pathways		Ligand-receptor interactions Activation of SMO
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Novel Interacting Genes		2 novel interacting genes: COL15A1 CYB5R3
Interacting Genes		5 interacting genes: BIRC2 DLK1 ERRFI1 PTPRA SHH
Entrez ID		2619
HPRD ID		00747
Ensembl ID		ENSG00000180447
Uniprot IDs		P54826
PDB IDs		7RHQ
Enriched GO Terms of Interacting Partners?		Lung Epithelium Development Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Collagen Type XV Trimer Steroid Metabolic Process Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Skin Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Vasculature Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Protein K48-linked Ubiquitination FBXO Family Protein Binding Nitric-oxide Synthase Complex Cholesterol Metabolic Process Sterol Metabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Intein-mediated Protein Splicing Cholesterol-protein Transferase Activity Prostate Epithelial Cord Elongation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Skeletal Muscle Cell Proliferation Bud Outgrowth Involved In Lung Branching Ventral Midline Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Specification Of Axis Polarity Trachea Morphogenesis Trachea Development Negative Regulation Of Dopaminergic Neuron Differentiation Hindgut Morphogenesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Positive Regulation Of Protein Monoubiquitination Nitrite Reductase (NO-forming) Activity Salivary Gland Cavitation Mesenchymal Cell Proliferation Involved In Lung Development Epithelial-mesenchymal Cell Signaling Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Trunk Neural Crest Cell Migration
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