GGA1 and SORT1

Number of citations of the paper that reports this interaction (PMID 11390366)
39

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		GGA1	SORT1
Gene Name		golgi-associated, gamma adaptin ear containing, ARF binding protein 1	sortilin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Endosome Membrane Membrane Clathrin Adaptor Complex Intracellular Membrane-bounded Organelle	Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Protein Binding	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G-protein Coupled Nerve Growth Factor Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process	Ossification Golgi To Endosome Transport Endocytosis G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organismal Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Coronary heart disease ( 21378988 21378990) LDL cholesterol ( 18193043 18193044 19060906 19060910 20686565) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Progranulin levels ( 21087763) Response to statin therapy ( 20339536)
Protein-Protein Interactions		36 interactors: AFTPH AP1AR APP ARF1 ARF3 ARF5 ARF6 BACE1 BACE2 C1orf216 CCDC91 CDKL3 CDKN2A CLINT1 CLTC CSNK2A1 DTNB F8 GGA2 GGA3 IGF2R LRP3 M6PR RAB5A RABEP1 RABGEF1 RNF11 RPS27A SMAD3 SORL1 SORT1 STAB1 SYNRG TSG101 UBC VPS18	8 interactors: BDNF GGA1 GGA2 LRPAP1 NGF NGFR NTS SORCS1
Entrez ID		26088	6272
HPRD ID		12078	03910
Ensembl ID		ENSG00000100083	ENSG00000134243
Uniprot IDs		Q6IC75 Q9UJY5	Q99523
PDB IDs		1J2J 1JWF 1JWG 1NA8 1NAF 1NWM 1O3X 1OM9 1OXZ 1PY1 1UJJ 1UJK 1X79 2DWX 2DWY 3G2S 3G2T 3G2U 3G2V 3G2W	3F6K 3G2U 3G2V
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Transport Protein Transport Establishment Of Protein Localization Endocytosis Intracellular Transport Protein Localization Establishment Of Localization In Cell Cellular Localization Post-Golgi Vesicle-mediated Transport Endosomal Transport Viral Protein Processing Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Protein Processing Regulation Of Cellular Component Organization Cellular Protein Localization Golgi Vesicle Transport Negative Regulation Of Protein Metabolic Process Intracellular Protein Transport Virion Assembly Apoptotic Process Programmed Cell Death Intracellular Transport Of Virus Cell Death Death Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Membrane Organization Regulation Of Mitotic Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Proteolysis Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Lysosomal Transport Positive Regulation Of Proteolysis Positive Regulation Of Wnt Signaling Pathway Regulation Of Cellular Localization Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Viral Process Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Growth Regulation Of Endocytosis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Viral Life Cycle Positive Regulation Of Cell Cycle Arrest	Regulation Of Axonogenesis Circadian Rhythm Cellular Response To Nerve Growth Factor Stimulus Response To Electrical Stimulus Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Regulation Of Axon Extension Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Response To Anesthetic Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Fluoxetine Response To L-glutamate Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nerve Development Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Regulation Of Stem Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Size Taste Bud Development Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Neuron Maturation Dendrite Extension Negative Regulation Of Hair Follicle Development Cellular Response To Norepinephrine Stimulus Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Hair Cycle Nerve Growth Factor Processing Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Apoptotic Process Axon Target Recognition Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Response To Norepinephrine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Response To Ether Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Death Regulation Of Cysteine-type Endopeptidase Activity Cell Projection Morphogenesis
Tagcloud ?		adpkd arl3 autosomal cilia ciliary ciliopathies cleaved couples golgi gps localize milieu module must pc1 pc2 polycystic polycystin proper proteolytically rabep1 reach sense tgn traffic trafficking transmembrane tubular whereby	aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified
Tagcloud (Difference) ?		adpkd arl3 autosomal cilia ciliary ciliopathies cleaved couples golgi gps localize milieu module must pc1 pc2 polycystic polycystin proper proteolytically rabep1 reach sense tgn traffic trafficking transmembrane tubular whereby	aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified
Tagcloud (Intersection) ?