GGA1 and SYNRG

Number of citations of the paper that reports this interaction (PubMedID 10747088)
37

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		GGA1	SYNRG
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 1	synergin gamma
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GO Annotations	Cellular Component	Nucleoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex	Cytoplasm Golgi Apparatus Membrane AP-1 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Plasma Membrane Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Catabolic Process Protein Localization To Cell Surface Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Ciliary Membrane	Intracellular Protein Transport Endocytosis Protein Transport
Pathways		TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS		Health literacy ( 31250787)	Lymphocyte count ( 32888494) Ovarian cancer ( 23535730) Response to angiotensin II receptor blocker therapy ( 22566498)
Interacting Genes		48 interacting genes: ADRA2B AFTPH AP1AR AP1G1 APP ARF1 ARF3 ARF5 ATXN7L1 BACE1 BACE2 C1orf216 CCDC91 CDKL3 CDKN2A CFTR CLINT1 CLTC CSNK2A1 DGCR6L DTNB EGFR ETS1 F8 GGA2 GGA3 GTPBP4 GTSE1 IGF2R ING5 JUN LRP3 M6PR NPM1 RABEP1 RABGEF1 RNF11 RPS27A SMAD3 SORL1 SORT1 STAB1 SYNRG TOLLIP TP53 TSG101 UBC VPS18	8 interacting genes: AP1G1 AP1G2 APPBP2 CCDC91 GGA1 GGA2 GGA3 SCAMP1
Entrez ID		26088	11276
HPRD ID		12078	06291
Ensembl ID		ENSG00000100083	ENSG00000275066
Uniprot IDs		Q9UJY5	Q9UMZ2
PDB IDs		1J2J 1JWF 1JWG 1NA8 1NAF 1NWM 1O3X 1OM9 1OXZ 1PY1 1UJJ 1UJK 1X79 2DWX 2DWY 3G2S 3G2T 3G2U 3G2V 3G2W	2MX7
Enriched GO Terms of Interacting Partners?		Early Endosome Endosome Protein Transport Establishment Of Protein Localization Intracellular Protein Transport Vesicle-mediated Transport Intracellular Transport Cellular Localization Endosome Membrane Vacuolar Transport Establishment Of Localization In Cell Clathrin-coated Vesicle Lysosomal Transport Intracellular Protein Localization Trans-Golgi Network Recycling Endosome Endocytosis Golgi Apparatus Early Endosome Membrane Import Into Cell Post-Golgi Vesicle-mediated Transport Establishment Of Protein Localization To Vacuole Perinuclear Region Of Cytoplasm Golgi Vesicle Transport Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Protein Localization To Vacuole Protein Targeting To Vacuole Positive Regulation Of MiRNA Transcription Receptor-mediated Endocytosis Negative Regulation Of Protein Metabolic Process Trans-Golgi Network Membrane Positive Regulation Of MiRNA Metabolic Process Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Protein Targeting To Lysosome Enzyme Binding Regulation Of Cell Growth Clathrin-coated Pit Ubiquitin Protein Ligase Binding Retromer Complex Binding Regulation Of Vesicle-mediated Transport Golgi To Lysosome Transport Nuclear Envelope Lumen AP-1 Adaptor Complex Establishment Of Protein Localization To Organelle Late Endosome Regulation Of Cell Cycle Regulation Of Growth Protein-containing Complex	Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Trans-Golgi Network Establishment Of Localization In Cell Intracellular Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization To Plasma Membrane Cellular Localization Golgi To Vacuole Transport Membrane Coat Protein Localization To Cell Surface Golgi Apparatus Golgi To Plasma Membrane Protein Transport Vacuolar Transport Cytoplasmic Vesicle Membrane Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Golgi To Plasma Membrane Transport Clathrin-coated Vesicle Small GTPase Binding Endosome Membrane Protein Localization To Membrane Golgi To Lysosome Transport AP-1 Adaptor Complex Ubiquitin Binding Endosome Phosphatidylinositol Binding Lysosomal Transport Cytosolic Transport Clathrin Adaptor Activity Vesicle-mediated Transport To The Plasma Membrane Intracellular Vesicle Localization Within Membrane Early Endosome Membrane Membrane Protein Localization To Cilium Early Endosome Synaptic Vesicle Budding From Endosome Recycling Endosome Membrane Trans-Golgi Network Membrane Protein Transport From Ciliary Membrane To Plasma Membrane Recycling Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Lysosomal Protein Catabolic Process
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