SYNRG and CCDC91

Number of citations of the paper that reports this interaction (PubMedID 12808037)
46

Data Source:
HPRD (in vitro)

		SYNRG	CCDC91
Description		synergin gamma	coiled-coil domain containing 91
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Membrane AP-1 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Protein Transport	Protein Transport Golgi Vesicle Transport Golgi To Lysosome Transport
Pathways
Drugs
Diseases
GWAS		Lymphocyte count ( 32888494) Ovarian cancer ( 23535730) Response to angiotensin II receptor blocker therapy ( 22566498)	Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (velocity of sound) ( 28472463) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) FEV1 ( 30804560) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hand osteoarthritis severity (hand Klsum) ( 33055079) Heel bone mineral density ( 30598549) Height ( 25282103 23563607 31562340 20881960 28552196) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082 28166213) Lung function (FVC) ( 26635082 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Narrowest width of the femoral neck ( 30888730) Obesity-related traits ( 23251661) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis of the hand ( 28855172) Peak expiratory flow ( 30804560) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
Interacting Genes		8 interacting genes: AP1G1 AP1G2 APPBP2 CCDC91 GGA1 GGA2 GGA3 SCAMP1	11 interacting genes: AP1G1 CDC37 DAPK2 ECT2 EWSR1 GGA1 GGA2 LNX1 PRR5L SYNRG TESC
Entrez ID		11276	55297
HPRD ID		06291	16905
Ensembl ID		ENSG00000275066	ENSG00000123106
Uniprot IDs		Q9UMZ2	Q05D28 Q7Z6B0
PDB IDs		2MX7	1OM9
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Trans-Golgi Network Establishment Of Localization In Cell Intracellular Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization To Plasma Membrane Cellular Localization Golgi To Vacuole Transport Membrane Coat Protein Localization To Cell Surface Golgi Apparatus Golgi To Plasma Membrane Protein Transport Vacuolar Transport Cytoplasmic Vesicle Membrane Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Golgi To Plasma Membrane Transport Clathrin-coated Vesicle Small GTPase Binding Endosome Membrane Protein Localization To Membrane Golgi To Lysosome Transport AP-1 Adaptor Complex Ubiquitin Binding Endosome Phosphatidylinositol Binding Lysosomal Transport Cytosolic Transport Clathrin Adaptor Activity Vesicle-mediated Transport To The Plasma Membrane Intracellular Vesicle Localization Within Membrane Early Endosome Membrane Membrane Protein Localization To Cilium Early Endosome Synaptic Vesicle Budding From Endosome Recycling Endosome Membrane Trans-Golgi Network Membrane Protein Transport From Ciliary Membrane To Plasma Membrane Recycling Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Lysosomal Protein Catabolic Process	Establishment Of Protein Localization Small GTPase Binding Clathrin-coated Vesicle Protein Transport Post-Golgi Vesicle-mediated Transport AP-1 Adaptor Complex Trans-Golgi Network Protein Localization To Plasma Membrane Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Surface Intracellular Protein Transport Protein Localization To Cell Periphery Intracellular Protein Localization Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Eosinophil Chemotaxis Autophagosome Lumen Golgi Vesicle Transport Golgi To Plasma Membrane Transport Protein Localization To Membrane Synaptic Vesicle Budding From Endosome Golgi Apparatus HSP90-CDC37 Chaperone Complex Positive Regulation Of Eosinophil Migration Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Transport Centralspindlin Complex Regulation Of Protein Phosphorylation Positive Regulation Of Sodium:proton Antiporter Activity Ubiquitin Binding Cellular Localization Phosphatidylinositol Binding Regulation Of Phosphorylation Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation
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