NRCAM and HSPA12A

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)

		NRCAM	HSPA12A
Description		neuronal cell adhesion molecule	heat shock protein family A (Hsp70) member 12A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Axon Cell Projection Neuron Projection Axon Initial Segment Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Angiogenesis Neuron Migration Cell Adhesion Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Brain Development Intracellular Protein Localization Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation Synapse Organization Cell-cell Adhesion Regulation Of Postsynapse Organization	Liver Development Inflammatory Response Macrophage Activation Import Into Nucleus
Pathways		Interaction between L1 and Ankyrins NrCAM interactions Neurofascin interactions	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Coffee consumption ( 21876539) Diastolic blood pressure ( 27841878) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333) White matter hyperintensity burden ( 25663218)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 26426971) Bone mineral density (hip) ( 30172743) Colorectal cancer ( 23263487) Freckles ( 29895819) Systolic blood pressure ( 30224653 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: ANK2 CNTN2 HSPA12A LCOR LNX1 MACF1 MAGI3 NFASC PTPRB RSPH1 VPS26C	4 interacting genes: HRAS M6PR NRCAM SORL1
Entrez ID		4897	259217
HPRD ID		07207	19074
Ensembl ID		ENSG00000091129	ENSG00000165868
Uniprot IDs		A0A1S5UZH4 B7Z670 C9JYY6 Q14CA1 Q92823	A0A1B0GTF3 A0A6I8PIT5 A0A6I8PLB1 B7Z2M8 O43301
PDB IDs		1UEN 1UEY
Enriched GO Terms of Interacting Partners?		Node Of Ranvier Axon Initial Segment	Protein Transporter Activity Protein Targeting To Lysosome Endocytosis Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Import Into Cell Protein Localization To Vacuole Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Early Endosome To Recycling Endosome Transport Lysosomal Transport GTPase Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Vacuolar Transport Phospholipase C Activator Activity Receptor-mediated Endocytosis Protein Targeting Trans-Golgi Network Protein Binding Involved In Heterotypic Cell-cell Adhesion Positive Regulation Of ER To Golgi Vesicle-mediated Transport Protein Retention In Golgi Apparatus Regulation Of Early Endosome To Recycling Endosome Transport Insulin Receptor Recycling Perinucleolar Compartment Transmembrane Signaling Receptor Activity Vesicle-mediated Transport Secretion Of Lysosomal Enzymes Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Triglyceride Catabolic Process Regulation Of Neurofibrillary Tangle Assembly Oncogene-induced Cell Senescence Aspartic-type Endopeptidase Inhibitor Activity Golgi Apparatus T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Retromer Complex Binding Establishment Of Protein Localization To Organelle Action Potential Propagation Neuronal Ion Channel Clustering Neuronal Action Potential Propagation Positive Regulation Of Endocytic Recycling Regulation Of ER To Golgi Vesicle-mediated Transport Amyloid-beta Formation Diet Induced Thermogenesis Positive Regulation Of Protein Localization To Early Endosome Nuclear Envelope Lumen Golgi Cisterna Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Localization To Endosome
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