NRCAM and CNTN2

Number of citations: 0 (PubMedID 12139915)
Data Source: BioGRID (pull down), HPRD (in vitro)

		NRCAM	CNTN2
Name		neuronal cell adhesion molecule	contactin 2
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Axon Cell Projection Neuron Projection Axon Initial Segment Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Cell Surface Membrane Axon Node Of Ranvier Neuron Projection Neuronal Cell Body Axon Initial Segment Myelin Sheath Juxtaparanode Region Of Axon Synapse Postsynaptic Membrane Side Of Membrane
	Molecular Function	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity	Protein Binding Carbohydrate Binding Cell Adhesion Mediator Activity Cell-cell Adhesion Mediator Activity
	Biological Process	Angiogenesis Neuron Migration Cell Adhesion Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Brain Development Intracellular Protein Localization Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation Synapse Organization Cell-cell Adhesion Regulation Of Postsynapse Organization	Microtubule Cytoskeleton Organization Neuron Migration G Protein-coupled Adenosine Receptor Signaling Pathway Response To Dietary Excess Reduction Of Food Intake In Response To Dietary Excess Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Neuron Differentiation Central Nervous System Myelination Regulation Of Cell Morphogenesis Regulation Of Axon Diameter Neuron Projection Development Receptor Internalization Clustering Of Voltage-gated Potassium Channels Fat Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Synapse Organization Establishment Of Localization In Cell Positive Regulation Of Adenosine Receptor Signaling Pathway Dendrite Self-avoidance Protein Localization To Juxtaparanode Region Of Axon Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization
Pathways		Interaction between L1 and Ankyrins NrCAM interactions Neurofascin interactions	L1CAM interactions NCAM1 interactions NrCAM interactions
GWAS		Blood protein levels ( 30072576 ) Coffee consumption ( 21876539 ) Diastolic blood pressure ( 27841878 ) Femoral neck bone geometry and menarche (age at onset) ( 23593202 ) Systolic blood pressure ( 27841878 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) White matter hyperintensities in ischemic stroke ( 26674333 ) White matter hyperintensity burden ( 25663218 )	Adventurousness ( 30643258 ) Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) HDL cholesterol levels ( 32203549 ) Mean platelet volume ( 24026423 ) Meat-related diet ( 32066663 ) Number of sexual partners ( 30643258 ) Periodontitis (stage III/IV grade C) ( 33745150 ) Red blood cell count ( 27863252 ) Schizophrenia ( 30285260 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: ELOC	1 novel interactors: NEK2
Interacting Genes		11 interacting genes: ANK2 CNTN2 HSPA12A LCOR LNX1 MACF1 MAGI3 NFASC PTPRB RSPH1 VPS26C	12 interacting genes: CDK4 CHEK1 CNTN1 CNTNAP2 EGFR L1CAM NCAN NFYB NRCAM TUBG1 UBE4B VAC14
Entrez ID		4897	6900
HPRD ID		07207	01826
Ensembl ID		ENSG00000091129	ENSG00000184144
Uniprot IDs		A0A1S5UZH4 B7Z670 C9JYY6 Q14CA1 Q92823	A1L3A3 Q02246
PDB IDs		1UEN 1UEY	2OM5 8K3J 8K53 9BA4 9BA5
GO Terms Enriched among Interactors		Node Of Ranvier Axon Initial Segment	Condensed Nuclear Chromosome Regulation Of Mitotic Centrosome Separation Neuron Projection Development Cell Adhesion Neuronal Ion Channel Clustering Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Axon Central Nervous System Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Cell-cell Adhesion Mediator Activity Plasma Membrane Bounded Cell Projection Organization Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell-cell Adhesion Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Neuron Projection Guidance Axon Guidance Neuron Recognition Brain Development Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Centriole-centriole Cohesion Nuclear Chromosome Segregation Granzyme-mediated Apoptotic Signaling Pathway PAS Complex Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Process Kinase Activity Cell Projection Organization Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Ciliary Basal Body Shc-EGFR Complex Microtubule Nucleator Activity Limbic System Development Superior Temporal Gyrus Development Regulation Of Axon Extension Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Protein Serine Kinase Activity Regulation Of Fibroblast Proliferation Histone H3T11 Kinase Activity Protein Phosphatase Binding Positive Regulation Of Protein Kinase C Signaling