NRCAM and PTPRB

Number of citations: 66 (PubMedID 9049255)
Data Source: BioGRID (pull down), HPRD (in vivo)

		NRCAM	PTPRB
Name		neuronal cell adhesion molecule	protein tyrosine phosphatase receptor type B
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Axon Cell Projection Neuron Projection Axon Initial Segment Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane
	Molecular Function	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding
	Biological Process	Angiogenesis Neuron Migration Cell Adhesion Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Brain Development Intracellular Protein Localization Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation Synapse Organization Cell-cell Adhesion Regulation Of Postsynapse Organization	Angiogenesis Osteoblast Differentiation Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Glial Cell Migration Dephosphorylation Developmental Process Negative Regulation Of Osteoblast Differentiation
Pathways		Interaction between L1 and Ankyrins NrCAM interactions Neurofascin interactions	Neutrophil degranulation
Drugs		None	{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
GWAS		Blood protein levels ( 30072576 ) Coffee consumption ( 21876539 ) Diastolic blood pressure ( 27841878 ) Femoral neck bone geometry and menarche (age at onset) ( 23593202 ) Systolic blood pressure ( 27841878 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) White matter hyperintensities in ischemic stroke ( 26674333 ) White matter hyperintensity burden ( 25663218 )	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 )
Novel Interactors		1 novel interactors: ELOC	1 novel interactors: CTNNB1
Interacting Genes		11 interacting genes: ANK2 CNTN2 HSPA12A LCOR LNX1 MACF1 MAGI3 NFASC PTPRB RSPH1 VPS26C	11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		4897	5787
HPRD ID		07207	01474
Ensembl ID		ENSG00000091129	ENSG00000127329
Uniprot IDs		A0A1S5UZH4 B7Z670 C9JYY6 Q14CA1 Q92823	F8VU56 P23467 Q86VA4
PDB IDs		1UEN 1UEY	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X 8JBN 8JBY
GO Terms Enriched among Interactors		Node Of Ranvier Axon Initial Segment	Cell Adhesion Protein Phosphatase Binding Regulation Of Cellular Component Organization Cell-cell Junction Anchoring Junction Cell Junction Cell-cell Adhesion Bicellular Tight Junction Cell-cell Adhesion Mediator Activity Regulation Of Endothelial Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Mechanical Stimulus Receptor Complex Cell Junction Organization Basal Plasma Membrane Developmental Process Animal Organ Development Membrane Anatomical Structure Morphogenesis Synapse Organization Cell Junction Assembly Glutamatergic Synapse Action Potential Propagation Neuronal Action Potential Propagation Regulation Of Rho Protein Signal Transduction Endothelial Cell Morphogenesis Regulation Of Developmental Process Cell Surface Cadherin Binding Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activator Activity Response To Estradiol Morphogenesis Of An Epithelium Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Cell-cell Junction Assembly Protein Localization To Cell-cell Junction Positive Regulation Of Homotypic Cell-cell Adhesion Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Tissue Morphogenesis Regulation Of Establishment Or Maintenance Of Cell Polarity Anatomical Structure Formation Involved In Morphogenesis