DPF2 and NFKB2

Number of citations of the paper that reports this interaction (PubMedID 20460684)
40

Data Source:
BioGRID (pull down)

		DPF2	NFKB2
Description		double PHD fingers 2	nuclear factor kappa B subunit 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SWI/SNF Complex NBAF Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity Histone H3K14ac Reader Activity Histone H4K16ac Reader Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of G0 To G1 Transition Apoptotic Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction Extracellular Matrix Organization Response To Lipopolysaccharide Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Intracellular Signaling Cassette
Pathways		Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection Regulation of PD-L1(CD274) transcription
Drugs			Sulfasalazine Donepezil Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Acne (severe) ( 24927181) Mean spheric corpuscular volume ( 32888494) Urate levels ( 31578528)	Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: FHL2 GOLGA6L9 H3-4 H3C1 H4C1 HSF2BP LDOC1 LNX1 MEOX2 NFKB2 PICK1 REL RELB RINT1 RUBCN TTC23L TXNDC12 UPF2 ZNF212 ZNF655	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		5977	4791
HPRD ID		03394	01239
Ensembl ID		ENSG00000133884	ENSG00000077150
Uniprot IDs		J3KMZ8 Q92785	Q00653
PDB IDs		3IUF 5B79 5VDC 6LTH 6LTJ	1A3Q 2D96 3DO7 4OT9 5ZMC 7CLI 7VUP 7VUQ 7W7L 8G8Q 8G8S
Enriched GO Terms of Interacting Partners?		NF-kappaB Complex Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interferon-beta Production Structural Constituent Of Chromatin Response To Muramyl Dipeptide Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm	Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Regulation Of Gene Expression Immune System Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Negative Regulation Of Biosynthetic Process Cytoplasm Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Nucleoplasm Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Defense Response NF-kappaB Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process
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