NOB1

Description		NIN1 (RPN12) binding protein 1 homolog
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Preribosome, Small Subunit Precursor
	Molecular Function	Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	RRNA Processing Visual Perception Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Blood osmolality (transformed sodium) ( 28360221) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 30578418)
Interacting Genes		3 interacting genes: APP PRNP UPF2
Entrez ID		28987
HPRD ID		11395
Ensembl ID		ENSG00000141101
Uniprot IDs		Q9ULX3
PDB IDs		6G18 6G4S 6G51 6G53 6G5I 6ZUO 6ZXD 6ZXE 6ZXF 7WTW 7WTX 7WTZ 7WU0 8ZDC
Enriched GO Terms of Interacting Partners?		Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Response To Copper Ion Molecular Function Activator Activity Response To Copper Ion Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Positive Regulation Of Calcium-mediated Signaling Response To Amyloid-beta Positive Regulation Of Neuron Apoptotic Process Regulation Of Calcium-mediated Signaling Protein-folding Chaperone Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Memory Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Postsynapse Organization Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Gene Expression Cellular Response To Metal Ion Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Membrane Raft PTB Domain Binding Protein Homooligomerization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synaptic Plasticity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium Ion Transport Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Postsynapse Regulation Of Neuron Apoptotic Process Protein Complex Oligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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