TIGIT

Gene Name		T cell immunoreceptor with Ig and ITIM domains
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: PVR PVRL2 PVRL3 PVRL4
Entrez ID		201633
HPRD ID		08804
Ensembl ID		ENSG00000181847
Uniprot IDs		Q495A1
PDB IDs		3Q0H 3RQ3 3UCR 3UDW
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Cell Adhesion Viral Entry Into Host Cell Entry Into Host Cell Cellular Component Assembly Viral Process Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of Adaptive Immune Response Fertilization Sperm Mitochondrion Organization Positive Regulation Of Innate Immune Response Viral Life Cycle Regulation Of Adaptive Immune Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Fusion Of Virus Membrane With Host Plasma Membrane Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Innate Immune Response Response To Virus Virion Attachment To Host Cell Adhesion Of Symbiont To Host Positive Regulation Of Mast Cell Activation Acrosome Assembly Establishment Of Mitochondrion Localization Single Organismal Cell-cell Adhesion Positive Regulation Of Immune Response Spermatid Nucleus Differentiation Lens Morphogenesis In Camera-type Eye Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Mitochondrion Localization
Tagcloud ?		abolish adapter asn227 disrupts dramatically engagement granule harbors immunoglobulin immunoreceptor itim itt killer killing ligation motif motifs nk phosphatidylinositol polarization poliovirus prematurely pvr recruit restoration ship1 tail terminate tyr225