TIGIT and ZDHHC23

Data Source: HiPPIP (Novel)

		TIGIT	ZDHHC23
Name		T cell immunoreceptor with Ig and ITIM domains	zDHHC palmitoyltransferase 23
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Activation	Protein Targeting To Membrane Protein Palmitoylation Protein Localization To Plasma Membrane
GWAS		No GWAS studies recorded	Crohn's disease and psoriasis ( 22482804 )
Novel Interactors		5 novel interactors: B4GALT4 CCDC191 GRAMD1C QTRT2 ZDHHC23	1 novel interactors: TIGIT
Interacting Genes		6 interacting genes: MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR	3 interacting genes: APP GLIS1 NOS1
Entrez ID		201633	254887
HPRD ID		08804	15717
Ensembl ID		ENSG00000181847	ENSG00000184307
Uniprot IDs		Q495A1	A0A1W2PRJ8 B3KXV3 E9PAP7 Q8IYP9
PDB IDs		3Q0H 3RQ3 3UCR 3UDW 5V52 7VYT 8JEL 8JEN 8JEO 8SZY	Not available
GO Terms Enriched among Interactors		Cell Adhesion Mediator Activity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Structural Constituent Of Myelin Sheath Virus Receptor Activity Cell Adhesion Molecule Binding Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Receptor Ligand Activity Positive Regulation Of Immune Response To Tumor Cell Cell-cell Contact Zone Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Cell-cell Adhesion Adherens Junction Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Establishment Of Protein Localization To Membrane Negative Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Negative Regulation Of Defense Response Membrane Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Lactosylceramide Biosynthetic Process Regulation Of Transcytosis TRNA-guanosine(34) Queuine Transglycosylase Activity TRNA Wobble Guanine Modification TRNA-guanine Transglycosylase Complex	Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Neurotransmitter Uptake Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Calcium-mediated Signaling Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Synaptic Signaling By Nitric Oxide Peptidyl-cysteine S-nitrosylase Activity Positive Regulation Of Macromolecule Metabolic Process Membrane Raft Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Calcium Ion Transport Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of The Force Of Heart Contraction Cadmium Ion Binding