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TIGIT and PVR
Number of citations of the paper that reports this interaction (PubMedID
21982860
)
0
Data Source:
BioGRID
(pull down)
TIGIT
PVR
Description
T cell immunoreceptor with Ig and ITIM domains
PVR cell adhesion molecule
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell Surface
Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Surface
Membrane
Molecular Function
Signaling Receptor Binding
Protein Binding
Signaling Receptor Activity
Identical Protein Binding
Virus Receptor Activity
Protein Binding
Signaling Receptor Activity
Receptor Ligand Activity
Cell Adhesion Molecule Binding
Cell Adhesion Mediator Activity
Biological Process
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-10 Production
Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of T Cell Activation
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Signal Transduction
Natural Killer Cell Mediated Cytotoxicity
Susceptibility To Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Symbiont Entry Into Host Cell
Susceptibility To T Cell Mediated Cytotoxicity
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Nectin/Necl trans heterodimerization
Drugs
Sphingosine
Myristic acid
Diseases
GWAS
Alzheimer's disease (
24755620
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Body mass index (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x age interaction (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Mean platelet volume (
27863252
32888494
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet distribution width (
32888494
)
Interacting Genes
6 interacting genes:
MAL
NECTIN2
NECTIN3
NECTIN4
PLLP
PVR
68 interacting genes:
ADIPOQ
ANKRD46
AP1M2
AQP10
BRICD5
C3orf52
CD226
CD47
CD96
CLDN19
CTXN3
CYB561A3
CYSRT1
DYNLT1
DYNLT3
EBP
EDDM3B
GPRC5D
HHATL
HOXA1
INSIG2
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
KRTAP3-3
KRTAP6-3
KRTAP9-3
MFSD11
NBPF19
NECTIN1
NECTIN3
NINJ1
NINJ2
NOTCH2NLA
OLFM4
PGA4
PLA2G3
PLP2
PLPP6
RUSF1
SCD
SLC30A2
SLC35B4
SLC41A2
SMIM1
SNAP47
SYS1
TAS2R19
TIGIT
TM6SF2
TMBIM6
TMEM147
TMEM229B
TMEM54
TMEM65
TMEM79
TSPO
VAMP5
VTN
WNK1
ZDHHC15
ZDHHC22
ZFPL1
ZFTRAF1
Entrez ID
201633
5817
HPRD ID
08804
01434
Ensembl ID
ENSG00000181847
ENSG00000073008
Uniprot IDs
Q495A1
A0A0A0MSA9
A0A0C4DG49
A8K4I1
P15151
PDB IDs
3Q0H
3RQ3
3UCR
3UDW
5V52
7VYT
8JEL
8JEN
8JEO
8SZY
1DGI
1NN8
3EPC
3EPD
3EPF
3J8F
3J9F
3UDW
3URO
4FQP
6ARQ
6ISC
6O3O
Enriched GO Terms of Interacting Partners
?
Cell Adhesion Mediator Activity
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Symbiont Entry Into Host Cell
Susceptibility To T Cell Mediated Cytotoxicity
Susceptibility To Natural Killer Cell Mediated Cytotoxicity
Biological Process Involved In Interaction With Host
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell
Regulation Of Natural Killer Cell Mediated Immunity
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Structural Constituent Of Myelin Sheath
Virus Receptor Activity
Cell Adhesion Molecule Binding
Negative Regulation Of Innate Immune Response
Regulation Of Leukocyte Mediated Cytotoxicity
Receptor Ligand Activity
Positive Regulation Of Immune Response To Tumor Cell
Cell-cell Contact Zone
Apical Junction Complex
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Response To Tumor Cell
Cell-cell Adhesion
Adherens Junction
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Immunity
Regulation Of Lymphocyte Mediated Immunity
Establishment Of Protein Localization To Membrane
Negative Regulation Of Immune Response
Natural Killer Cell Mediated Cytotoxicity
Natural Killer Cell Mediated Immunity
Regulation Of T Cell Mediated Cytotoxicity
Protein Insertion Into Plasma Membrane
Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane
Coreceptor-mediated Virion Attachment To Host Cell
Cellular Anatomical Entity Morphogenesis
Negative Regulation Of Defense Response
Membrane
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of Cell Killing
Positive Regulation Of T Cell Mediated Immunity
Leukocyte Mediated Cytotoxicity
Sperm Mitochondrion Organization
Lactosylceramide Biosynthetic Process
Regulation Of Transcytosis
TRNA-guanosine(34) Queuine Transglycosylase Activity
TRNA Wobble Guanine Modification
TRNA-guanine Transglycosylase Complex
Keratin Filament
Intermediate Filament
Apical Junction Complex
Membrane
Cell Adhesion Mediator Activity
Establishment Of Protein Localization To Membrane
Identical Protein Binding
Membrane Destabilizing Activity
Regulation Of Natural Killer Cell Mediated Immunity
Cell-cell Contact Zone
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Cochlea Morphogenesis
Regeneration
Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell
Protein Binding
Cell Adhesion
Positive Regulation Of Mast Cell Activation
Steroid Biosynthetic Process
Cholesterol Biosynthetic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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