TIGIT and CCDC191

Data Source: HiPPIP (Novel)

		TIGIT	CCDC191
Name		T cell immunoreceptor with Ig and ITIM domains	coiled-coil domain containing 191
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	None
	Molecular Function	Signaling Receptor Binding Protein Binding Signaling Receptor Activity Identical Protein Binding	None
	Biological Process	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Activation	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		6 interacting genes: MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR	None recorded
Entrez ID		201633	57577
HPRD ID		08804	13856
Ensembl ID		ENSG00000181847	ENSG00000163617
Uniprot IDs		Q495A1	Q8NCU4
PDB IDs		3Q0H 3RQ3 3UCR 3UDW 5V52 7VYT 8JEL 8JEN 8JEO 8SZY	Not available
GO Terms Enriched among Interactors		Cell Adhesion Mediator Activity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Structural Constituent Of Myelin Sheath Virus Receptor Activity Cell Adhesion Molecule Binding Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Receptor Ligand Activity Positive Regulation Of Immune Response To Tumor Cell Cell-cell Contact Zone Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Cell-cell Adhesion Adherens Junction Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Establishment Of Protein Localization To Membrane Negative Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Negative Regulation Of Defense Response Membrane Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Lactosylceramide Biosynthetic Process Regulation Of Transcytosis TRNA-guanosine(34) Queuine Transglycosylase Activity TRNA Wobble Guanine Modification TRNA-guanine Transglycosylase Complex	Positive Regulation Of Interleukin-10 Production Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Regulation Of Interleukin-12 Production Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Cytotoxicity Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Negative Regulation Of T Cell Activation Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Immune Response Cell Killing Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Cell Activation Signaling Receptor Activity