NSL1 and SUGT1

Number of citations of the paper that reports this interaction (PubMedID 22869522)
42

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NSL1	SUGT1
Description		NSL1 component of MIS12 kinetochore complex	SGT1 assembly cochaperone of MIS12 kinetochore complex
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol Nuclear Speck	Ubiquitin Ligase Complex Kinetochore Nucleus Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Protein-folding Chaperone Binding LncRNA Binding
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division	Spindle Organization Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: CBX5 DSN1 G6PC1 HSP90AA1 LRRK2 MIS12 SUGT1	18 interacting genes: BUB3 CEBPA CSNK2A1 DSN1 FNDC3B HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1
Entrez ID		25936	10910
HPRD ID		12378	09160
Ensembl ID		ENSG00000117697	ENSG00000165416
Uniprot IDs		Q53FM2 Q5SY74 Q96IY1	A8K7W3 B4DYC6 Q9Y2Z0
PDB IDs		4NF9 5LSI 5LSJ 5LSK 8PPR 8Q5H	1RL1
Enriched GO Terms of Interacting Partners?		Kinetochore MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Cell Proliferation Kinetochore Assembly Kinetochore Organization Chromosome, Centromeric Region Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Mitochondrion Muscle Cell Proliferation CTP Binding Chromosome Organization DATP Binding Regulation Of Protein Stability Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Neurofibrillary Tangle Assembly UTP Binding Protein-containing Complex Assembly Sulfonylurea Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Glucose-6-phosphatase Activity Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding Positive Regulation Of Protein Autoubiquitination Response To Curcumin Transmembrane Transporter Binding Protein-containing Complex Organization Chromosome Segregation Response To Resveratrol Glucose-6-phosphate Transport Sperm Mitochondrial Sheath Chromosome Spindle Pole Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Telomerase Holoenzyme Complex Assembly Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis	MIS12/MIND Type Complex Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation Chromosome, Centromeric Region Kinetochore Spindle Pole Protein Localization To Organelle Chromosome Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Nuclear Chromosome Segregation Nucleus Negative Regulation Of Cell Cycle Identical Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Chromosome Separation Calcium-dependent Protein Binding Endothelial Cell Migration S100 Protein Binding Regulation Of DNA Metabolic Process Nucleoplasm Protein Localization To Chromosome Positive Regulation Of Catabolic Process Chaperone-mediated Protein Complex Assembly Memory Protein Import Into Mitochondrial Matrix Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Hormone Regulation Of DNA Recombination Regulation Of Chromosome Segregation PcG Protein Complex Establishment Of Protein Localization To Organelle Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Chromosome Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Cell Cycle Protein Homodimerization Activity Positive Regulation Of Inflammatory Response Protein Localization To Mitochondrion Negative Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-dependent Protein Catabolic Process
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