NSL1 and MIS12

Number of citations of the paper that reports this interaction (PubMedID 15502821)
0

Data Source:
HPRD (in vitro, in vivo)

		NSL1	MIS12
Description		NSL1 component of MIS12 kinetochore complex	MIS12 kinetochore complex component
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol Nuclear Speck	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: CBX5 DSN1 G6PC1 HSP90AA1 LRRK2 MIS12 SUGT1	9 interacting genes: CBX3 CBX5 DSN1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		25936	79003
HPRD ID		12378	12379
Ensembl ID		ENSG00000117697	ENSG00000167842
Uniprot IDs		Q53FM2 Q5SY74 Q96IY1	A8K1M4 Q9H081
PDB IDs		4NF9 5LSI 5LSJ 5LSK 8PPR 8Q5H	5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Kinetochore MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Cell Proliferation Kinetochore Assembly Kinetochore Organization Chromosome, Centromeric Region Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Mitochondrion Muscle Cell Proliferation CTP Binding Chromosome Organization DATP Binding Regulation Of Protein Stability Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Neurofibrillary Tangle Assembly UTP Binding Protein-containing Complex Assembly Sulfonylurea Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Glucose-6-phosphatase Activity Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding Positive Regulation Of Protein Autoubiquitination Response To Curcumin Transmembrane Transporter Binding Protein-containing Complex Organization Chromosome Segregation Response To Resveratrol Glucose-6-phosphate Transport Sperm Mitochondrial Sheath Chromosome Spindle Pole Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Telomerase Holoenzyme Complex Assembly Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis	Outer Kinetochore Chromosome, Centromeric Region Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Skeletal Muscle Cell Proliferation Nuclear Chromosome Segregation Chromosome Cell Division Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Nuclear Body Muscle Cell Proliferation Regulation Of Meiosis I Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Nucleus Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Kinetochore Organization Positive Regulation Of Cell Cycle Checkpoint Nucleoplasm Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Pole Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Pericentric Heterochromatin Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Nuclear Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Site Of DNA Damage Regulation Of Chromosome Organization Heterochromatin Positive Regulation Of Cell Cycle Process Regulation Of TRNA Methylation Kinetochore Adaptor Activity Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Meiotic Cell Cycle
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