NSL1 and G6PC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NSL1	G6PC1
Description		NSL1 component of MIS12 kinetochore complex	glucose-6-phosphatase catalytic subunit 1
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol Nuclear Speck	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Glucose-6-phosphatase Activity Protein Binding Phosphotransferase Activity, Alcohol Group As Acceptor Hydrolase Activity Phosphate Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division	Glycogen Metabolic Process Glycogen Catabolic Process Gluconeogenesis Triglyceride Metabolic Process Steroid Metabolic Process Response To Carbohydrate Regulation Of Gene Expression Glucose-6-phosphate Transport Response To Nutrient Levels Response To Food Response To Insulin Cellular Response To Insulin Stimulus Multicellular Organism Growth Glucose Homeostasis Cholesterol Homeostasis Urate Metabolic Process Chemical Homeostasis Glucose 6-phosphate Metabolic Process Lipid Homeostasis Response To Caloric Restriction Response To Resveratrol
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Glycogen storage disease type Ia (G6PC) Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		7 interacting genes: CBX5 DSN1 G6PC1 HSP90AA1 LRRK2 MIS12 SUGT1	4 interacting genes: CDH16 FOXO1 NSL1 SNX13
Entrez ID		25936	2538
HPRD ID		12378	01983
Ensembl ID		ENSG00000117697	ENSG00000131482
Uniprot IDs		Q53FM2 Q5SY74 Q96IY1	P35575
PDB IDs		4NF9 5LSI 5LSJ 5LSK 8PPR 8Q5H	9J7U 9J7V
Enriched GO Terms of Interacting Partners?		Kinetochore MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Cell Proliferation Kinetochore Assembly Kinetochore Organization Chromosome, Centromeric Region Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Mitochondrion Muscle Cell Proliferation CTP Binding Chromosome Organization DATP Binding Regulation Of Protein Stability Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Neurofibrillary Tangle Assembly UTP Binding Protein-containing Complex Assembly Sulfonylurea Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Glucose-6-phosphatase Activity Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding Positive Regulation Of Protein Autoubiquitination Response To Curcumin Transmembrane Transporter Binding Protein-containing Complex Organization Chromosome Segregation Response To Resveratrol Glucose-6-phosphate Transport Sperm Mitochondrial Sheath Chromosome Spindle Pole Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Telomerase Holoenzyme Complex Assembly Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis
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