HSPA12A and SORL1

Number of citations of the paper that reports this interaction (PubMedID 30679749)
52

Data Source:
BioGRID (pull down, imaging technique)

		HSPA12A	SORL1
Description		heat shock protein family A (Hsp70) member 12A	sortilin related receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Golgi Cisterna Multivesicular Body Membrane Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Perinucleolar Compartment
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Low-density Lipoprotein Particle Binding Small GTPase Binding Neuropeptide Binding Protein Transporter Activity
	Biological Process	Liver Development Inflammatory Response Macrophage Activation Import Into Nucleus	Diet Induced Thermogenesis Protein Targeting Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Neuropeptide Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Protein Localization To Golgi Apparatus Amyloid-beta Formation Insulin Receptor Recycling Retrograde Transport, Endosome To Golgi Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Neurogenesis Positive Regulation Of Protein Exit From Endoplasmic Reticulum Endosome To Plasma Membrane Protein Transport Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Amyloid-beta Formation Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Adipose Tissue Development Adaptive Thermogenesis Positive Regulation Of Endocytic Recycling
Pathways		Regulation of HSF1-mediated heat shock response	Amyloid fiber formation
Drugs
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 26426971) Bone mineral density (hip) ( 30172743) Colorectal cancer ( 23263487) Freckles ( 29895819) Systolic blood pressure ( 30224653 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 23565137 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Atrial fibrillation ( 30061737 29892015) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Cadmium levels ( 26025379) Cardiovascular risk factors (age interaction) ( 20838585) Estimated glomerular filtration rate ( 31152163 31451708) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Mood disorder in prion disease ( 25897833) Non-word reading ( 30741946) Problematic alcohol use ( 32451486) Rheumatic heart disease ( 34106200) Smoking status (ever vs never smokers) ( 30643258) Spontaneous preterm birth (preterm birth) ( 25599974) Word reading ( 30741946)
Interacting Genes		4 interacting genes: HRAS M6PR NRCAM SORL1	12 interacting genes: APOE ERBB2 ERBB3 FURIN GGA1 GGA2 HSPA12A LRPAP1 POU6F2 PPP1CA RHOH SORT1
Entrez ID		259217	6653
HPRD ID		19074	03595
Ensembl ID		ENSG00000165868	ENSG00000137642
Uniprot IDs		A0A1B0GTF3 A0A6I8PIT5 A0A6I8PLB1 B7Z2M8 O43301	Q92673
PDB IDs			2DM4 3G2S 3G2T 3WSX 3WSY 3WSZ 7VT0
Enriched GO Terms of Interacting Partners?		Protein Transporter Activity Protein Targeting To Lysosome Endocytosis Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Import Into Cell Protein Localization To Vacuole Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Early Endosome To Recycling Endosome Transport Lysosomal Transport GTPase Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Vacuolar Transport Phospholipase C Activator Activity Receptor-mediated Endocytosis Protein Targeting Trans-Golgi Network Protein Binding Involved In Heterotypic Cell-cell Adhesion Positive Regulation Of ER To Golgi Vesicle-mediated Transport Protein Retention In Golgi Apparatus Regulation Of Early Endosome To Recycling Endosome Transport Insulin Receptor Recycling Perinucleolar Compartment Transmembrane Signaling Receptor Activity Vesicle-mediated Transport Secretion Of Lysosomal Enzymes Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Triglyceride Catabolic Process Regulation Of Neurofibrillary Tangle Assembly Oncogene-induced Cell Senescence Aspartic-type Endopeptidase Inhibitor Activity Golgi Apparatus T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Retromer Complex Binding Establishment Of Protein Localization To Organelle Action Potential Propagation Neuronal Ion Channel Clustering Neuronal Action Potential Propagation Positive Regulation Of Endocytic Recycling Regulation Of ER To Golgi Vesicle-mediated Transport Amyloid-beta Formation Diet Induced Thermogenesis Positive Regulation Of Protein Localization To Early Endosome Nuclear Envelope Lumen Golgi Cisterna Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Localization To Endosome	Endosome ERBB3:ERBB2 Complex Endosome Membrane Very-low-density Lipoprotein Particle Receptor Binding ErbB-3 Class Receptor Binding Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Amyloid-beta Clearance ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Localization To Membrane Post-Golgi Vesicle-mediated Transport Early Endosome Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Schwann Cell Development Regulation Of Amyloid-beta Clearance ERBB2 Signaling Pathway Golgi Apparatus Low-density Lipoprotein Particle Receptor Binding Regulation Of Membrane Protein Ectodomain Proteolysis Peripheral Nervous System Development Heparin Binding Protein Localization To Cell Surface Cellular Localization Plasma Lipoprotein Particle Remodeling Trans-Golgi Network Golgi To Plasma Membrane Protein Transport Protein-containing Complex Remodeling Localization Within Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Growth Factor Binding Protein Localization To Cell Periphery Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Neurotensin Receptor Activity, Non-G Protein-coupled Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Golgi To Plasma Membrane Transport Golgi Vesicle Transport
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