HSPA12A and M6PR

Number of citations of the paper that reports this interaction (PubMedID 30679749)
52

Data Source:
BioGRID (two hybrid)

		HSPA12A	M6PR
Description		heat shock protein family A (Hsp70) member 12A	mannose-6-phosphate receptor, cation dependent
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Exosome	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Protein Transporter Activity Retromer Complex Binding
	Biological Process	Liver Development Inflammatory Response Macrophage Activation Import Into Nucleus	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Glycosphingolipid Catabolic Process
Pathways		Regulation of HSF1-mediated heat shock response	Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Glycosphingolipid catabolism
Drugs			Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 26426971) Bone mineral density (hip) ( 30172743) Colorectal cancer ( 23263487) Freckles ( 29895819) Systolic blood pressure ( 30224653 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)	Sjögren's syndrome ( 28076899) Total cholesterol levels ( 30275531) Type 1 diabetes ( 34127860)
Interacting Genes		4 interacting genes: HRAS M6PR NRCAM SORL1	12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4
Entrez ID		259217	4074
HPRD ID		19074	01106
Ensembl ID		ENSG00000165868	ENSG00000003056
Uniprot IDs		A0A1B0GTF3 A0A6I8PIT5 A0A6I8PLB1 B7Z2M8 O43301	F5GX30 P20645
PDB IDs			1JUQ
Enriched GO Terms of Interacting Partners?		Protein Transporter Activity Protein Targeting To Lysosome Endocytosis Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Import Into Cell Protein Localization To Vacuole Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Early Endosome To Recycling Endosome Transport Lysosomal Transport GTPase Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Vacuolar Transport Phospholipase C Activator Activity Receptor-mediated Endocytosis Protein Targeting Trans-Golgi Network Protein Binding Involved In Heterotypic Cell-cell Adhesion Positive Regulation Of ER To Golgi Vesicle-mediated Transport Protein Retention In Golgi Apparatus Regulation Of Early Endosome To Recycling Endosome Transport Insulin Receptor Recycling Perinucleolar Compartment Transmembrane Signaling Receptor Activity Vesicle-mediated Transport Secretion Of Lysosomal Enzymes Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Triglyceride Catabolic Process Regulation Of Neurofibrillary Tangle Assembly Oncogene-induced Cell Senescence Aspartic-type Endopeptidase Inhibitor Activity Golgi Apparatus T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Retromer Complex Binding Establishment Of Protein Localization To Organelle Action Potential Propagation Neuronal Ion Channel Clustering Neuronal Action Potential Propagation Positive Regulation Of Endocytic Recycling Regulation Of ER To Golgi Vesicle-mediated Transport Amyloid-beta Formation Diet Induced Thermogenesis Positive Regulation Of Protein Localization To Early Endosome Nuclear Envelope Lumen Golgi Cisterna Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Localization To Endosome	Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Endosome Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Macrophage Activation Golgi Vesicle Transport Small GTPase Binding Leading Edge Cell Differentiation Protein Localization To Membrane Cellular Response To Anisomycin Juxtaglomerular Apparatus Development Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Triglyceride Storage
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