HSPA12A

Description		heat shock protein family A (Hsp70) member 12A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Liver Development Inflammatory Response Macrophage Activation Import Into Nucleus
Pathways		Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 26426971) Bone mineral density (hip) ( 30172743) Colorectal cancer ( 23263487) Freckles ( 29895819) Systolic blood pressure ( 30224653 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		4 interacting genes: HRAS M6PR NRCAM SORL1
Entrez ID		259217
HPRD ID		19074
Ensembl ID		ENSG00000165868
Uniprot IDs		A0A1B0GTF3 A0A6I8PIT5 A0A6I8PLB1 B7Z2M8 O43301
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Transporter Activity Protein Targeting To Lysosome Endocytosis Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Import Into Cell Protein Localization To Vacuole Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Early Endosome To Recycling Endosome Transport Lysosomal Transport GTPase Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Vacuolar Transport Phospholipase C Activator Activity Receptor-mediated Endocytosis Protein Targeting Trans-Golgi Network Protein Binding Involved In Heterotypic Cell-cell Adhesion Positive Regulation Of ER To Golgi Vesicle-mediated Transport Protein Retention In Golgi Apparatus Regulation Of Early Endosome To Recycling Endosome Transport Insulin Receptor Recycling Perinucleolar Compartment Transmembrane Signaling Receptor Activity Vesicle-mediated Transport Secretion Of Lysosomal Enzymes Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Triglyceride Catabolic Process Regulation Of Neurofibrillary Tangle Assembly Oncogene-induced Cell Senescence Aspartic-type Endopeptidase Inhibitor Activity Golgi Apparatus T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Retromer Complex Binding Establishment Of Protein Localization To Organelle Action Potential Propagation Neuronal Ion Channel Clustering Neuronal Action Potential Propagation Positive Regulation Of Endocytic Recycling Regulation Of ER To Golgi Vesicle-mediated Transport Amyloid-beta Formation Diet Induced Thermogenesis Positive Regulation Of Protein Localization To Early Endosome Nuclear Envelope Lumen Golgi Cisterna Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Localization To Endosome
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